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Rise in maternal age has led to increase in pregnancies affected by Down's syndrome

BMJ 2006; 332 doi: (Published 25 May 2006) Cite this as: BMJ 2006;332:1234
  1. Roger Dobson
  1. Abergavenny

    Increases in the numbers of older mothers has led to a rise in the number of pregnancies affected by Down's syndrome in Europe.

    Some European regions have shown a more than twofold increase in total prevalence of Down's syndrome since 1980, say researchers from the European Surveillance of Congenital Anomalies, a network of population-based registries for the epidemiological surveillance of congenital anomalies covering around one quarter of births in the European Union.

    According to the report in Revue d'épidémiologie et de santé publique (2005; 53: 2587-95), Down syndrome makes up around 8% …

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