Intended for healthcare professionals

News Roundup [abridged Versions Appear In The Paper Journal]

Antidepressants double suicidality in children, says FDA

BMJ 2006; 332 doi: (Published 16 March 2006) Cite this as: BMJ 2006;332:626
  1. Jeanne Lenzer
  1. New York

    Children and adolescents treated with antidepressants are nearly twice as likely to develop suicidality—suicidal thinking and behaviour—as similar children treated with placebo. This is the finding of a meta-analysis of 24 studies by the US Food and Drug Administration. The studies tested 4582 patients taking nine antidepressants versus placebo for major depressive disorder, obsessive-compulsive disorder, generalised anxiety disorder, attention deficit or hyperactivity disorder, and social anxiety disorder.

    The FDA's analysis, published in this month's Archives of General Psychiatry is the final review of data that were previously analysed but not released by the FDA (2006;63:332-9). News of the secret data emerged in August 2004, and led to criticism of the FDA when it was learnt that Andrew …

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