Risk of gastrointestinal effects with COX-2 inhibitors and NSAIDs: COX-2 inhibitors were thought of as a safe option

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7530.1474-b (Published 15 December 2005) Cite this as: BMJ 2005;331:1474
  1. Michael R Lewis, general practitioner (Michael.Lewis@gp-w96010.wales.nhs.uk)1,
  2. Diana Kay, general practitioner2
  1. 1 Welshpool Medical Centre, Powys SY21 7ER
  2. 2 Cheam Family Practice, Sutton, Surrey SM1 2HD

    EDITOR—The study by Hippisley-Cox et al into the safety of cyclo-oxygenase-2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDS) is subject to more indication bias than they suggest.1

    When the study began, five years ago, COX-2 inhibitors were widely regarded …

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