Intended for healthcare professionals

Clinical Review

Treatment of bites by adders and exotic venomous snakes

BMJ 2005; 331 doi: (Published 24 November 2005) Cite this as: BMJ 2005;331:1244

This article has a correction. Please see:

  1. David A Warrell, professor of tropical medicine and infectious diseases (david.warrell{at}
  1. 1 Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
  • Accepted 13 October 2005


Every year, hundreds of people and unknown numbers of dogs and other domestic animals in England, Wales, and Scotland are bitten by our only indigenous venomous snake, the adder (Vipera berus) (fig 1). UK poisons centres are consulted about an average of 100 human and a dozen veterinary cases each year. In about 70% of patients, envenoming is negligible or purely local, causing pain, swelling, and inflammation of the bitten digit. Only 14 fatalities have been reported since 1876,1 the last in a 5 year old child in 1975,w1 but adder bites should not be underestimated. On rare occasions, envenoming can be life threatening, especially in children, and many adults experience prolonged discomfort and disability after the bite.

Fig 1
Fig 1

Adder or viper (Vipera berus)

Apart from the exotic venomous snakes held legally by zoos, research establishments, and licensed private individuals, large numbers of dangerous snakes are kept surreptitiously as macho pets in the United Kingdom, Ireland, and other countries.2 3w2-w8 This “underground zoo”w9 reveals itself on average only five or six times each year in the UK when bitten owners are forced to seek medical help.4

Sources and selection criteria

I have based this review on personal experience in clinical research on snake bites and as an adviser to the National Poisons Centre since 1986 and to the Zoological Society of London and other UK zoos. Other sources were my personal archive of books, papers, and unpublished case reports; discussions and correspondence with other experts; and searches of Medline, PubMed, and Google.

Adder bites

The adder or viper (Vipera berus) is common throughout mainland Britain and some of the islands off the west coast of Scotland. Bites occur from February to October, peaking in June to August. Half the patients are bitten on the hand while picking up the adder.

Clinical features

Local envenoming—Immediate sharp pain is followed, usually within a few minutes but sometimes up to more than 30 minutes later, by a sensation of tingling and local swelling that spreads proximally. Local blisters containing blood are uncommon. Spreading pain, tenderness, inflammation (often described misleadingly as “cellulitis,” although there is no infection), and tender enlargement of regional lymph nodes are sometimes noticeable within hours. Reddish lymphangitic lines and bruising appear, and the whole limb may become swollen and bruised within 24 hours (fig 2) with involvement of the trunk and, in children, the whole body (fig 3). Suspected intracompartmental syndromes and necrosis are very rare.w10

Fig 2
Fig 2

Extensive swelling of the bitten limb in a child, 24 hours after the bite, showing bruising

Fig 3
Fig 3

Generalised swelling and bruising of the whole body in an infant (courtesy of Hans Persson, Stockholm)

Systemic envenoming—Dramatic anaphylactoid symptoms may appear within five minutes of the bite (see case history) or may be delayed for many hours. These include nausea; retching; vomiting; abdominal colic; diarrhoea; incontinence of urine and faeces; sweating; fever; vasoconstriction; tachycardia; light-headedness; loss of consciousness; shock; angiooedema of the face, lips, gums, tongue, throat, and epiglottis; urticaria; and bronchospasm.5 w11 These symptoms may persist or fluctuate for as long as 48 hours in the absence of treatment. Hypotension is a most critical sign. It usually develops within two hours and may resolve spontaneously, persist, recur, or progress fatally. Clinical features of a bleeding diathesis are unusual,w12-w14 but bleeding from the gums and nose and into the lungs (fig 4), 6 gastrointestinal and genitourinary tracts, and serosal cavities and retroperitoneally can occur. The risk of bleeding is greatly increased by misguided treatment with heparin. Fatal haemothorax, massive haematemesis and melaena, haematuria, and intrauterine fetal death are rare tragedies. Acute renal failure has often been described, especially in children. Increased capillary permeability is reflected by the local and sometimes generalised oedema, as well as the more focal angio-oedema that can lead to fatal occlusion of the upper airway, pulmonary oedema,w15 and cerebral oedema. Coma and seizures have been attributed to hypotension, cerebral oedema, hyponatraemia, hypoalbuminaemia, or hypoxaemia secondary to respiratory distress.7 Cardiac arrest, acute gastric dilatation, paralytic ileus, and acute pancreatitisw16 are other reported complications.

Fig 4
Fig 4

Chest radiograph showing interstitial pulmonary haemorrhage in a child bitten three days earlier (courtesy of R Pugh, Hull)


Neutrophil leucocytosis is common. Initial haemo-concentration and later anaemia result from extravasation into the bitten limb and perhaps haemolysis. Concentrations of serum creatine kinase, transaminases, urea, and creatinine may be raised, and bicarbonate may be reduced. Thrombocytopeniaw12 and mild coagulopathy—reflected by prolonged prothrombin time (international normalised ratio), activated partial thromboplastin time, hypofibrinogenaemia, and raised fibrin degradation products or D-dimer—is sometimes detected. Consumption coagulopathy and incoagulable blood (20 minute whole blood clotting testw17) are uncommon.8

Electrocardiographic changes include tachyarrhythmias, bradyarrhythmias, atrial fibrillation, flattening or inversion of T waves, ST elevation or depression, second degree heart block, and frank myocardial infarction.1 5


First aid

Initial management is to reassure, give paracetamol to control pain, and immobilise the whole patient (especially the bitten limb with a splint or sling) during urgent transport to hospital. Early anaphylactoid symptoms can be treated with an oral or parenteral H1 blocker or adrenaline (epinephrine) (Epi-Pen), depending on severity. Any interference with the wound should be avoided. Tourniquets, ligatures, and compression bandages should not be used.

Hospital treatment

In hospital, rapid clinical assessment of the degree of envenoming and resuscitation may be needed, followed by careful monitoring of the blood pressure and evolution of envenoming over at least 24 hours. The most important decision is whether antivenom should be given.


This specific antidote prevents mortality and reduces hospital stay and morbidity,811 w18 but it is underused in the UK. Zagreb antivenom has been provided to NHS hospitals since 1969. Other effective antivenoms are Protherics ViperaTAb12 w19 and Sanofi-Pasteur Viperfav.w20 w21 Zagreb antivenom has also proved safe and effective in V berus envenomed dogs.w22 w23 Indications for antivenom are

  • Hypotension with or without signs of shock

  • Other signs of systemic envenoming (see above), electrocardiographic abnormalities, peripheral neutrophil leucocytosis, elevated serum creatine kinase, or metabolic acidosis

  • Local swelling that is either extensive (involving more than half the bitten limb within 48 hours of the bite) or rapidly spreading (beyond the wrist after bites on the hand or beyond the ankle after bites on the foot within about four hours of the bite).

Two ampoules of Zagreb antivenom are given (exactly the same dose for infants and children) by slow intravenous injection or infusion; 0.1% adrenaline (plus intravenous antihistamine and hydrocortisone) should be drawn up in case of early anaphylactoid antivenom reactions, which complicate about 10% of treatments with Zagreb antivenom.8 These reactions are not predicted by intradermal hypersensitivity tests.13 Their frequency may be reduced by giving prophylactic subcutaneous adrenaline (adult dose 0.25 mg of 0.1%)14 but is not affected by H1 blockers.15 If no clinical improvement has occurred after one hour, the initial dose of two ampoules of antivenom can be repeated. Late serum sickness reactions can be treated with oral H1 blockers or corticosteroids.

Other management

Intravenous fluids or blood transfusion may be needed to correct hypovolaemia and anaemia from massive extravasation into the tissues. The bitten limb should be nursed in the most comfortable position, but excessive elevation should be avoided. Contractures (such as result in equinus deformity) from prolonged bed rest must be prevented by splinting, and rehabilitation physiotherapy should be started as early as possible.

Case history: near fatal adder bite in 1998

While walking with her husband near the Blackwater Estuary in Essex, a 39 year old woman stepped off the path on to a grass verge and immediately felt a very painful sharp stinging sensation on her left foot (she was wearing open sandals). Her mouth felt dry, she became dizzy and nauseated, and she had to lie down. Her throat was closing up, she could not swallow or breathe, and within five minutes she had lost consciousness. Her husband rushed away to call an ambulance, but when he returned he found two strangers doing cardiopulmonary resuscitation on her. She looked very pale and was vomiting and doubly incontinent. She had two cardiorespiratory arrests before the ambulance arrived 30 minutes later. She was given two injections of adrenaline intramuscularly and assisted ventilation with oxygen by mask. When she arrived at hospital 50 minutes after the “sting,” her Glasgow coma score was 11/15, her blood pressure was 86/60 mm Hg, and her pulse was 138 beats/minute. On her left foot were two fang punctures 6 mm apart, with swelling and bruising up to mid-calf. Adder bite was diagnosed. Her leucocyte count was 15.3×109/l (neutrophilia), international normalised ratio 1.65, prothrombin time 19.1 seconds (control 14.0), and platelets 150×109/l. Electrocardiograms showed widespread ST segment depression suggesting global ischaemia. These abnormalities resolved completely in a few hours, and she made a slow recovery after treatment with antivenom. She had never been bitten before.


Children usually recover completely between less than a week and three weeks after the bite, but most adults take three weeks or longer, and a quarter take between one and nine months. During recovery, disabling aching and intermittent swelling of the bitten limb may occur.1

Fig 5
Fig 5

Pressure-immobilisation method

Exotic snake bites

More than 75 species of exotic venomous snakes are kept legally and illegally in the UK. They include the most popular “pet” species listed below (genera in parentheses), members of three families:

  • Elapidae—cobras (Naja), including spitters, coral snakes (Micrurus, Micruroides), kraits (Bungarus), mambas (Dendroaspis)

  • Viperidae—rattlesnakes (Crotalus, Sistrurus); copperhead moccasins and cantils (Agkistrodon); bush vipers (Atheris); puff adders, Gaboon vipers, rhinoceros horned vipers (Bitis); desert horned vipers (Cerastes); green pit vipers (Trimeresurus)

  • Colubridae—boomslangs (Dispholidus), Montpellier snakes (Malpolon), red-necked keel backs, and yamakagashis (Rhabdophis).

People are bitten by exotic snakes while handling or feeding them, cleaning out their cages, milking them of their venoms, or attempting to steal them. Some pet keepers are bitten while handling their snakes in a drunken, drugged, tired, or emotional state, late at night.

Clinical features1618w24

Only about 50% of bites by exotic venomous snakes inject sufficient venom to cause clinical envenoming.

Local envenoming—Swelling, bleeding, bruising, lymphangitis, blistering, necrosis, secondary infection, and painful regional lymph node enlargement are typical of bites by many species of Viperidae. Cobras can cause local swelling, blistering, and necrosis; other Elapidae such as kraits, coral snakes, and Australian death adders produce negligible local envenoming.

Systemic envenoming—Bleeding diatheses (spontaneous systemic bleeding from the gums, nose, or gastrointestinal and genitourinary tracts, incoagulable blood, platelet abnormalities) are common after bites by Viperidae, Colubridae, and Australasian Elapidae. Microangiopathic and intravascular haemolysis (some Elapidae, Colubridae, and Viperidae),4 generalised rhabdomyolysis (sea snakes, Australasian Elapidae, and some Viperidae), and hypotension and shock (Viperidae)19 contribute to the risk of acute renal failure. Descending paralysis, starting with ptosis and external ophthalmoplegia and progressing to respiratory failure, is typical of bites by Elapidae (including sea snakes) and a few species of Viperidae. Spitting cobras and the South African rinkhals spray their venom defensively from the tips of their fangs into the eyes, causing painful chemical conjunctivitis with the risk of corneal ulceration, anterior uveitis, and secondary infection. The eyes should be irrigated immediately with generous volumes of water.


First aid for most exotic bites is the same as for adder bites (see above), but pressure-immobilisation (fig 5)20 21 is recommended for bites by snakes that can cause rapidly evolving and life threatening paralysis (most elapids except African spitting cobras and some Asian cobras).

Practical problems of management include

  • Finding and identifying the snake responsible. Zoos and poisons centres can often suggest an expert herpetologist.w25 An emailed electronic image of the animal can be life saving

  • Obtaining the appropriate antivenom urgently through the national poisons centre.2Antivenoms selected to cover the venomous species known and suspected to be held in the UK are stored in London and Liverpool

  • Persuading the pet keeper to stay in hospital long enough to be treated.

Antivenom is indicated if there are haemostatic abnormalities (incoagulable blood or spontaneous systemic bleeding), shock, neurotoxicity, myotoxicity, nephrotoxicity, or severe local envenoming.22 w26 w27

Supportive treatment

Circulating volume repletion and dopamine may be effective for hypotension and adrenaline (epinephrine) for the rare cases of venom anaphylaxis in snake handlers who have become hypersensitive to venom.

Early endotracheal intubation and assisted ventilation are needed if neurotoxicity progresses. Anti-cholinesterase drugs improve some cases of neurotoxic envenoming.23

Heparin, corticosteroids, and antifibrinolytic agents should not be used. Secondary bacterial infection of the bite wound may occur with abscess formation, but prophylactic antibiotics are not justified.24 Fasciotomy is very rarely indicated despite common clinical appearances suggesting intracompartmental syndrome and should not be allowed without full restoration of normal haemostasis and demonstration that intracompartmental pressure is > 40 mm Hg.25

Additional educational resources

The clinical management of snake bites in the South East Asian region—

Clinical toxinology resources—

American Zoo and Aquarium Association. Bites by exotic Elapidae—accessible via under “Recommendations, procedures and discussion”


Munich AntiVenomINdex (MAVIN)—

CSL Antivenom Handbook—

Antivenom index— (for poisons centers' prescribers)

World Health Organization—

Venomous snake taxonomy updates—

Summary points

Life threatening envenoming by adders is uncommon but can happen, especially in children—do not underestimate the humble adder

Envenoming can evolve over many hours, so patients must be carefully observed in hospital for at least 24 hours after being bitten

Antivenom is effective and acceptably safe in hospitals; it is underused in the United Kingdom

Antivenom should be considered in patients with systemic envenoming, especially children, and in those who have extensive or rapidly progressing local swelling

Thousands of exotic snakes of more than 75 different species are kept legally and illegally in the UK; identification of the species, obtaining appropriate antivenom, and completing treatment are some of the clinical challenges


I am grateful to R David, G Theakston, Ian M Stell, Alexander Campbell, and Glyn N Volans for useful information.


  • Embedded Image Extra references are on

  • Competing interests None declared.


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