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Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.38623.768588.47 (Published 17 November 2005) Cite this as: BMJ 2005;331:1169

Data supplement

  • References

    1. Ancoli-Israel S, Walsh JK, Mangano RM, Fujimori M. Zaleplon A. Novel nonbenzodiazepine hypnotic, effectively treats insomnia in elderly patients without causing rebound effects. Prim Care Companion J Clin Psychiatry 1999;1:114-120.
    2. Bayer AJ, Pathy MS, Ankier SI. An evaluation of the short-term hypnotic efficacy of loprazolam in comparison with nitrazepam in elderly patients. Pharmatherapeutica 1983;3:468-74.
    3. Bayer A, Pathy MSJ. Clinical and psychometric evaluation of 2 doses of loprazolam and placebo in geriatric patients. Curr Med Res Opinion 1986;10:17-24.
    4. Dehlin O, Bjornson J. Triazolam as a hypnotic for geriatric patients. Act PsychiatrScand 1983;67:290-6.
    5. Dehlin O, Rubin B, Rundgren A. Double-blind comparison of zopiclone and flunitrazepam in elderly insomniacs with special focus on residual effects. Curr Med Res Opinion 1995;13:317-24.
    6. Elie R, Frenay M, Le Morvan P, Bourgouin J. Efficacy and safety of zopiclone and triazolam in the treatment of geriatric insomniacs. Int Clin Psychopharmacol 1990;5(suppl 2):39-46.
    7. Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of zolpidem on subjective sleep, psychomotor performance and cognitive function in elderly volunteers. Eur J Clin Pharmacol 1992;43:597-601.
    8. Hedner J, Yaeche R, Emilien G, Farr I, Salinas E. Zaleplon shortens subjective sleep latency and improves subjective sleep quality in elderly patients with insomnia. The Zaleplon Clinical Investigator Study Group. Int J Geriatr Psychiatry 2000;15:704-12.
    9. Klimm H, Dreyfus JF, Delmotte M. Zopiclone vs. nitrazepam: a double-blind comparative study of efficacy and tolerance in elderly patients with chronic insomnia. Sleep 1987;10:73-8.
    10. Lachnit K, Proszolowski E, Rieder L. Midazolam in the treatment of sleep disorders in geriatric patients. Br J Clin Pharmac 1983;16 (suppl):173-7S.
    11. Leppik I, Roth-Schecheter GB, Gray GW, Cohn MA, Owens D. Double-blind, placebo-controlled comparison of zolpidem, triazolam, and temazepam in elderly patients with insomnia. Drug Dev Res 1997;40:230-8.
    12. Mamelak M, Csima A, Buck L, Price V. A comparative study on the effects of brotizolam and flurazepam on sleep and performance in the elderly. J Clin Psychopharm 1989;9:260-7.
    13. Meuleman JR, Nelson RC, Clark RL Jr. Evaluation of temazepam and diphenhydramine as hypnotics in a nursing-home population. Drug Intell Clin Pharm 1987;21:716-20.
    14. Morin C, Colecchi C, Stone J, Sood R, Brink D. Behavioural and pharmacological therapies for late-life insomnia: a randomized controlled trial. JAMA 1999;281:991-9.
    15. Murphy P, Hindmarch I, Hyland CM. Aspects of short-term use of two benzodiazepine hypnotics in the elderly. Age Ageing 1982;11:222-8.
    16. Overstall P, Oldman PN. A comparative study of lormetazepam and chlormethiazole in elderly in-patients. Age Ageing 1987;16:45-51.
    17. Reeves R. Comparison of triazolam, flurazepam, and placebo as hypnotics in geriatric patients with insomnia. J Clin Pharmacol 1977;17:319-23.
    18. Richards HH, Valle-Jones CJ. A double-blind comparison of two lormetazepam doses in elderly insomniacs. Curr Med Res Opin 1988;11:48-55.
    19. Roger M, Attali R, Coquelin JP. Multicentre, double-blind, controlled comparison of zolpidem and triazolam in elderly patients with insomnia. Clin Therapeutics 1993;15:127-36.
    20. Viukari M, Vartio T, Verho E. Low doses of brotizolam and nitrazepam as hypnotics in the elderly. Neuropsychobiol 1984;12:130-3.
    21. Bayer A, Bayer EM, Pathy MSJ, Stoker MJ. A double-blind controlled study of chlomethiazole and triazolam as hypnotics in the elderly. Acta PsychiatrScand 1986;73:104-11.
    22. Caldwell JR. Short-term quazepam treatment of insomnia in geriatric patients. Pharmatherapeutica 1982;3:278-82.
    23. Mouret J, Ruel D, Maillard F, Bianchi M. Zopiclone versus triazolam in insomniac geriatric patients: a specific increase in delta sleep with zopiclone. Int Clin Psychopharmacol 1990;5(suppl 2):47-55.
    24. Roth T, Roehrs TA, Ksohorek GL, Greenblatt DJ, Rosenthal. Hypnotic effects of low doses of quazepam in older insomniacs. J Clin Psychopharmacol 1997;17:401-6.

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