Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.38611.658947.55 (Published 03 November 2005) Cite this as: BMJ 2005;331:1053
References to studies included in the meta analysis
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w27 Gardemann A, Weidemann H, Philpp M, Katz N, Tillmanns H, Wilhelm Herlein F, et al. The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk of coronary artery disease. Eur Heart J 1999;20:584-92.
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w33 Tokgozoglu SL, Alikasifoglu M, Unsal I, Atalar E, Aytemir K, Ozer N, et al. Methylenetetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate. Heart 1999;81:518-22.
w34 Malik NM, Syrris P, Schwartsman R, Kaski JC, Crossman DC, Francis SE, et al. Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. Clin Sci 1998;95:311-5.
w35 Thögersen AM, Nilsson TK, Dahlen G, Jansson J-H, Boman K, Huhtasaari F, et al. Homozygosity for the C677→ T mutation of 5,10-methylenetetrahydrofolate reductase and total plasma homocyst(e)ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden. Coron Artery Dis 2001;12:85-90.
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w37 Nakai K, Fusazaki T, Suzuki T, Ohsawa M, Kamata J, Kawazoe K, et al. Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population. Coron Artery Dis 2000;11:47-51.
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w39 Szczeklik A, Sanak M, Jankowski M, Dropinski J, Czachór R, Musial L, et al. Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia. Am J Med Genet 2001;101:36-9.
w40 Ou T, Kobayashi Y, Yamakawa K, Arinami T, Amemiya H, Fujiwara H, et al. Methylenetetrahydrofolate reductase and apolipoprotein E polymorphisms are independent risk factors for coronary heart disease in Japanese: a case control study. Atherosclerosis 1998;137:23-8.
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