Participants in research: Routine extrapolation of randomised controlled trials is absurd

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.331.7508.109-b (Published 07 July 2005) Cite this as: BMJ 2005;331:109
  1. Bruce G Charlton, reader in evolutionary psychiatry (bruce.charlton@ncl.ac.uk)
  1. School of Biology, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU

    EDITOR—For more than a decade it has been an article of faith in evidence based medicine that randomised controlled trials are “best evidence” and their findings can routinely be extrapolated to clinical situations.1 In his editorial Sackett, the founder of evidence based medicine, seeks retrospectively to reassure clinicians that this practice was justifiable, but the accompanying study by Vist et …

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