Aspirin + PPI is safer than clopidogrel if patient has history of GI bleeding

Question What is the best antithrombotic for patients with a history of upper gastrointestinal (GI) bleeding?

Synopsis Clopidogrel has been recommended by the American College of Cardiology as the preferred drug for patients who require an antithrombotic agent to prevent heart disease but who also have a history of bleeding peptic ulcer. This study compared clopidogrel with the combination of aspirin and esomeprazole in this setting. Patients with a source of upper gastrointestinal bleeding (52% gastric ulcer, 34% …