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Clinical Review Interactive case report

Postoperative hypoxia in a woman with Down's syndrome: case outcome

BMJ 2005; 330 doi: (Published 05 May 2005) Cite this as: BMJ 2005;330:1068
  1. A K Siotia, research fellow in cardiology (,
  2. A Chaudhuri, specialist registrar in acute medicine2,
  3. S I Muzulu, consultant endocrinologist3,
  4. D Harling, consultant anaesthetist3,
  5. R Muthusamy, consultant cardiologist3
  1. 1 Northern General Hospital, Sheffield, S5 7AU,
  2. 2 Ninewells Hospital, Dundee,
  3. 3 Rotherham District General Hospital, Rotherham, S60 2UD
  1. Correspondence to: A K Siotia

    Five weeks ago (9 April, p 834) we presented the case of Miss Webb, a 24 year old woman with Down's syndrome, who developed postoperative hypoxia after a hysterectomy for menorrhagia. She was subsequently found to have a pericardial effusion.

    A full blood count done on her second admission showed a high mean corpuscular volume of 109.8 (normal range 80-100) fl. Her liver function results and vitamin B12 and folate concentrations were normal. Thyroid function tests showed a thyroid stimulating hormone concentration of 63.7 (0.5-4.1) mIU/l and free T4 of 2.57 (10.3-25.3) pmol/l. Severe hypothyroidism with multiple …

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