Intended for healthcare professionals

Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care

Jill Porthouse, Sarah Cockayne, Christine King, Lucy Saxon, Elizabeth Steele, Terry Aspray, Mike Baverstock, Yvonne Birks, Jo Dumville, Roger Francis, Cynthia Iglesias, Suezann Puffer, Anne Sutcliffe, Ian Watt, David J Torgerson
Table 2

Odds of fracture in women receiving calcium and cholecalciferol (vitamin D3) supplementation (intervention group) and those receiving only advice on diet and prevention of falls. Values are percentages (numbers) unless stated otherwise

Confirmed fracturesIntervention group (n=1321)Control group (n=1993)Adjusted odds ratio (95% CI)*P value
All fractures:
Unequally allocated group4.8 (34/714)5.0 (69/1391)1.01 (0.71 to 1.43)0.97
Equally allocated group4.0 (24/607)3.7 (22/602)
Hip fractures:
Unequally allocated group0.4 (3/714)1.1 (15/1391)0.75 (0.31 to 1.78)0.51
Equally allocated group0.8 (5/607)0.3 (2/602)
Hip and wrist fractures:
Unequally allocated group2.4 (17/714)3.2 (44/1391)0.89 (0.56 to 1.44)0.64
Equally allocated group2.0 (12/607)1.5 (9/602)
  • * Adjusted for practice.

  • † Two women randomised to control group for every one allocated to treatment group.