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News Roundup [abridged Versions Appear In The Paper Journal]

Vitamin E doesn't slow progression to Alzheimer's disease

BMJ 2005; 330 doi: (Published 21 April 2005) Cite this as: BMJ 2005;330:923
  1. David Spurgeon
  1. Quebec

    Vitamin E, a widely used early intervention for Alzheimer's disease, had no effect on 769 patients with mild cognitive impairment enrolled in a three year randomised placebo controlled doubleblind study published online on 13 April by the New England Journal of Medicine (, doi:10.1056/NEJMoa050151). The study also showed that although donepezil (Aricept)showed no slowing of the rate of progression of the disease after three years compared with placebo, the drug was associated with a lower rate of progression during the first 12 months of treatment. Patients with an apolipoprotein E allele, which is a risk factor for Alzheimer's disease, showed a significant effect at one, two, and …

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