Letters
Clomipramine and neuroleptic malignant syndrome
BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7494.790-c (Published 31 March 2005) Cite this as: BMJ 2005;330:790Literature on adverse reactions to psychotropic drugs continues to confuse
- Geoffrey K Isbister (gsbite@ferntree.com), clinical toxicologist,
- Nicholas A Buckley, associate professor
- Newcastle Mater Misericordiae Hospital, Edith Street, Waratah, NSW 2298, Australia
- Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
EDITOR—Haddow et al describe a severe adverse drug reaction but create an oxymoron in describing clomipramine induced “neuroleptic malignant syndrome.”1
Clomipramine is not a neuroleptic and therefore by definition cannot cause this syndrome (any more than it can cause anti-convulsant hypersensitivity syndrome). The description is consistent with serotonin toxicity, a well described adverse …
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