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Authors of TADS study reply to letter raising concerns

BMJ 2005; 330 doi: (Published 24 March 2005) Cite this as: BMJ 2005;330:730
  1. John S March (, chief, Child and Adolescent Psychiatry Program for Child Affective and Anxiety Disorders

    for the TADS Group

  1. Duke University Child and Family Study Center, 718 Rutherford Street, Room 132, DUMC 3527, Durham, NC 27710, USA

EDITOR—We thank Jureidini et al for their interest in the treatment for adolescents with depression study (TADS) study1 but find their critique to lack accuracy, methodological sophistication, scientific rigour, and credibility.

TADS does not consist of “two separate randomised studies.” Patients were consecutively randomised to one of the four TADS treatments using a computerised, stratified randomisation algorithm.2 3 Because comparative treatment trials that include both medication and psychotherapy conditions …

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