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New cholera vaccine is effective among people with HIV

BMJ 2005; 330 doi: (Published 24 February 2005) Cite this as: BMJ 2005;330:438
  1. Scott Gottlieb
  1. New York

    A new, orally administered cholera vaccine has been shown to be effective against clinically significant cholera in an urban sub-Saharan population with a high prevalence of HIV infection.

    The results offer one of the best possibilities for improved control of cholera, even among HIV infected people, who may not respond well to other cholera vaccines.

    The results come from an evaluation in Beira, Mozambique—a city where the seroprevalence of HIV is 20% to 30%—of a mass immunisation programme with an oral cholera vaccine consisting of recombinant cholera toxin B subunit and killed whole cells (the rBS-WC vaccine) (New England Journal of Medicine 2005;352:757-67). The World Health Organization …

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