Varicella vaccination for healthcare workers
BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7489.433 (Published 24 February 2005) Cite this as: BMJ 2005;330:433All rapid responses
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Judy Breuer appears to be attempting a veritable marketing exercise
for varicella vaccine in the UK, is this acceptable?
Judy cites all the usual 'scare tactic' questionable data -varicella
MAY kill, varicella MAY BE bad for you, varicella MAY cost a lot to treat,
etc. etc. through her
"Chickenpox in immunosuppressed people, pregnant women, and infants
born to seronegative mothers may lead to life threatening pneumonitis and
other complications in 10-30% and is fatal in 15-25 patients every year.
Maternal varicella in the first 20 weeks carries a 1-2% risk of congenital
varicella syndrome for the fetus."
Then she cleverly tempers her enthusiasm with...
"Although 95% of adult patients born in the United Kingdom and staff
are immune to chickenpox, only 75-85% of adults who have grown up in
tropical countries such as the Philippines, the Indian subcontinent, and
the West Indies are immune. Hospitals with high numbers of staff or
patients from these area are at greater risk of nosocomial outbreaks. The
close proximity of infected cases (children with chickenpox and adults
with zoster) to susceptible patients and staff within the hospital
provides an ideal environment for viral transmission to occur"
If immigrant populations are at risk then sensibly, and to remove any
expectation of ADRs from the vaccine from our nationals, it is they who
(if they so wish) should be vaccinated perhaps before embarking to this
Isle. Those who have no protection against this relatively innocuous
illness due to immigration, who are children, ought to consider locating a
'chickenpox party' to develop lifelong immunity. Adults who emigrated, as
we who travel or emigrate abroad, would/should have already considered any
risks from chickenpox their immigration might have posed in a country that
does not use the vaccine as it is an innocuous disorder of childhood.
Why put this population at risk from any vaccine either by direct or
indirect contact with the vaccine/vaccinated, especially in hospitals
where many people with diagnosed and undiagnosed illnesses of all kinds
might be at risk from the recently vaccinated worker they contact without
knowing the vaccine status of that hospital worker - a vaccine that by
indirect (through a vaccinated person)contact might induce an 'atypical'
infection in that already compromised patient?
Perhaps the good Professor can elaborate on the risks of
contamination to unsuspecting patients, suffering from all kinds of
diseases one may find in hospital, from recently vaccinated workers and...
How often does one experience zoster, though an unwanted
infection, passing from family member to family member despite close
proximity? IN THE UK
Thence what of zoster patients and close contact workers - what is
the real risk of infection from such a patient? IN THE UK
How many zoster patients are hospitalised per annum? IN THE UK
How many chickenpox cases are hospitalised per annum? IN THE UK
How many susceptible hospital workers would be likely to have to deal
with these cases? IN THE UK
Note I have emphasied IN THE UK ito avoid the ages old marketing ploy
of providing figures from the deepest, darkest, areas of the world where
chickenpox and shingles would likely wipe out whole populations...
Regards
John H.
Competing interests:
None declared
Competing interests: No competing interests
Varicella vaccination is generally considered safe [1] but there are usually no prescreening tests to determine whether an adverse reaction is likely to occur [2]. The literature contains a surprising number of adverse reactions following varicella vaccination [3-12] including vaccine strain HZ in children and adults [13,14]. The Advisory Committee on Immunization Practices (ACIP) states, "VAERS data are limited by underreporting and unknown sensitivity of the reporting system, making it difficult to compare adverse event rates following vaccination reported to VAERS with those from complications following natural disease. Nevertheless, the magnitude of these differences makes it likely that serious adverse events following vaccination occur at a substantially lower rate than following natural disease [15]." Since follow-up is not conducted, it may be argued that some reports may not be attributed to or associated with vaccination and therefore the true rate of adverse events is essentially unknown. Nevertheless, VAERS rates have been estimated to represent 5% to 10% of the true figure of adverse reactions. The lot number associated with each vaccine is recorded in the VAERS data base. However, the CDC and FDA have never required the vaccine manufacturers to publicly divulge the number of vaccines contained in a given lot. This prevents researchers from determining "hot lots" since calculation of the number of adverse reactions per lot is not possible.
Table 1 presents a comparison of the number of adverse reactions reported to VAERS for the varicella vaccine with 4 other different vaccines. The high mean of 3,000 reports/year is attributed to the Hepatitis B vaccine, followed next by a mean of 2,350 reports/year attributed to varicella vaccine (Table 1). The first report of an adverse reaction following varicella vaccination was filed with VAERS (ID 74221) on May 26, 1995. This 3.5-year-old boy from Georgia who had no pre-existing conditions, received a dose of varicella vaccine on May 12, 1995. He developed convulsions the following day, was hospitalized, and reportedly recovered.
Table 1. VAERS reports associated with Varicella, DTaP, Hep B, Hib, and MMR vaccines through December, 2003
Vaccine type | Reports | Date of first reports | Duration (years) | Mean (cases/yr) |
Varicella | 20,004 | 12 May 1995 | 8.5 | 2,350 |
DTap | 23,886 | 2 Apr 1992 | 11.4 | 2,080 |
Hep B | 41,708 | 25 Jan 1990 | 14 | 2,980 |
Hib | 25,060 | 2 Jan 1990 | 14 | 1,790 |
MMR | 31,132 | 17 Nov 1989 | 14 | 2,220 |
Source information from U.S. Government VAERS data base, 1990-2003, http://www.medalerts.org/vaersdb
Many physicians consider vaccination extremely safe and parents or patients are not provided with information regarding potential adverse outcomes. Since varicella disease is relatively benign, only a few serious adverse reactions might offset the intended benefits.
Wrensch et al. suggest a novel finding that adults who have not had prior varicella-zoster virus (VZV) infection (including onset of chickenpox) are more likely to have gliomas (brain tumors) than adults who have had prior infection [10]. The brain tumor pathogenesis is not fully understood at this time.
Clinical descriptions of five different serious adverse affects that followed varicella vaccination are given below.
Case “A”
A 35-year old female who had never had varicella, was exposed to infected children. Her physician recommended prompt vaccination and she received a first dose of varicella vaccine on May 18, 1998. Approximately two hours following vaccination, a transient welt developed at the injection site with a 3-inch line of lymphangitis. Eight days after vaccination, she developed a fever, sore throat, nausea, vomiting, malaise and dizziness. She noticed some bruises and had aching in her knees, hands and feet. She was seen by her physician because of an irregular heart rate and an ECG revealed supra ventricular extra systoles and left ventricular hypertrophy. Her CPK was elevated to 676. Her nausea and vomiting persisted for the next three months despite use of anti-nausea medication. She was admitted to a hospital for rehydration after losing 12 lbs or more than 10% of her previous healthy weight. The patient later developed a cough, marked fatigue, sensitivity to light and sound, disturbed sleep and more serious loss of appetite. These symptoms along with dizziness persisted for weeks and she had difficulty going from her bed to the bathroom without assistance. By the sixth month post-vaccination, she was seen by a neurologist and a physiatrist. Both thought that she could have Guillian-barre syndrome. An EMG revealed involvement in an ulnar distribution. The patient's nausea decreased and her fever subsided. Her joint pains became episodic but more intense during the attacks and she experienced some muscle weakness on and off. Gradually she was able to work for a few hours at a time. A VAERS report was filed January 30, 2000.
Case “B”
A man who was vaccinated against varicella in 1995 developed encephalomyloneuritis and required hospitalization for months. He remains permanently disabled.
Case “C”
An adult female, age 47, became disabled following varicella vaccination. She worked as a research coordinator in the infectious disease unit of a Medical School. She and other immune employees were recruited as healthy controls for a manufacturer-sponsored vaccine study aimed at detecting the boosting effect of the vaccine. Her pre-study laboratory values were completely normal. She received a first dose of the vaccine in March and the second in May 2001. She developed diarrhea shortly after the second dose and by November 2001, she was quite ill and had serious intestinal difficulties. She underwent a colonoscopy and was diagnosed with the rare and more serious collagenous colitis. While her lymphocytes decreased from 25 to 14%, her total white count, neutrophils and eosinophils increased. She was told that her collagenous colitis was autoimmune in nature. She remains disabled and out of work and the event has been reported to VAERS.
Case “D”
A 17-month-old female toddler received the varicella vaccination on March 20, 1996. Her older brother reacted to all vaccinations and developed late-onset autism following his MMR. D’s mother was initially fearful and refused the varicella vaccine for her daughter. Her physician reassured her by saying: “Do you think I would give the vaccination to my own children if I thought it wasn't safe?” Her physician also informed her that state law mandates chickenpox vaccination but never told her that she could withhold her consent. The mother says that she felt “humiliated into allowing her daughter to receive the varicella vaccine.” Shortly afterwards, “D” began having joint pains, eczema and allergies. Her symptoms worsened at the age of 6. Her ANA became positive and she developed autoimmune thyroid disease with a high TSH. Her skin sensitivity also became more intense. Her physician was of the opinion that a virus probably triggered her autoimmune response.
Case “E”
This boy was born on June 30, 1998 and received the varicella vaccination on June 29, 2000. Twenty-eight months following varicella vaccination (October 29, 2002), he developed breakthrough chickenpox with an estimated 30 to 40 lesions that were intensely itchy. He was listless and had some rhinorhea but remained afebrile.
On June 12, 2003 (age 5), he had a unilateral shingles eruption on the back of his neck. He had moderate pain and the lesions were tender and sensitive to clothing. In spite of treatment with Acyclovir* the rash lasted for 45 days.
Nine months later on March 10, 2004 he had a recurrence of shingles affecting the left nipple and the left side of the back. This time, the pain was more severe. He was treated again with Acyclovir. The rash slowly subsided but left scars.
Two months later on May 13, 2004 he had still another recurrence with moderate pain, in the same location as previously mentioned. He received a third course of Acyclovir and the rash resolved after a month.
Each of the three occurrences of the shingles rash was on his left side. He took Acyclovir Oral Suspension (200mg/5ml): Two teaspoons 4 times a day for 5 days.
Conclusion
Cost-benefit analyses of varicella vaccination appear optimistic, but they fail to factor in the resulting deleterious effects. Analyses of the universal varicella vaccination program in the U.S. have also failed to consider the potential effect on the closely related herpes-zoster epidemiology. Exogenous exposures to wild type varicella have previously contributed a significant immunologic boosting effect that helps suppress the reactivation of herpes-zoster. In the U.S. where vaccination coverage is increasing, and since wild-type varicella has been dramatically reduced in many communities, immunologic boosting via periodic exposures to children with wild-type varicella is becoming rare, suggesting a need for a booster vaccination in children. Universal Varicella Vaccination program assumptions that (1) a single dose offered long-term immunity, and (2) there is no immunologically-mediated link between varicella incidence and herpes-zoster incidence are seriously flawed.
References
1. BRAUN MM, MOOTREY GT, SEWARD JF, RIDER LG, KRAUSE PR: Postlicensure safety surveillance for varicella vaccine. JAMA. (2000) 284:1271-1279.
2. POSER CM: Neurological Complications of Vaccinations. Mealey’s Litigation Report, Thimerosal & Vaccines (April, 2003) Volume 1, Issue #10.
** The author writes concerning neurological complications, "There is no way of predicting who will have an adverse reaction to vaccination. The individual's susceptibility is determined by the genetic background and previous immunological history. We are constantly exposed to a wide variety of viral antigens that cause our immune system to develop antibodies against them. The phenomenon of molecular mimicry explains why some people's immune system will mistakenly respond to the measles antigen, for instance, in the vaccine because some of its amino acid groupings, its epitopes, are the same as those in the protein of a previously encountered viral antigen."
3. RAVKINA LI, MATSEVICH GR: Morphological changes in the central nervous system in post-vaccinal encephalomyelitis developing after chickenpox vaccination in children. Zh. Nevropatol. Psikhiatr. Im. S. S. Korsakova. (1970) 70(10):1465-1471.
4. SUNAGA Y, HIKIMA A, OSTUKA T, MORIKAWA A: Acute cerebellar ataxia with abnormal MRI lesions after varicella vaccination. Pediatr. Neurol. (1995) 13(4):340-342.
* Two-year-old boy with staggering gait and difficulty speaking.
5. SINGER S, JOHNSON CE, MOHR R, HOLOWECKY C: Urticaria following varicella vaccine associated with gelatin allergy. Vaccine (1999) 17(4):327-329.
6. GERECITANO J, FRIEDMAN-KIEN A, CHAZEN GD: Allergic reaction to varicella vaccine. Ann. Intern. Med. (1997) 126(10):833-834.
7. SAKAGUCHI M, YAMANAKA T, IKEDA K, SANO Y, FUJITA H, MIURA T, INOUYE S: IgE-mediated systemic reactions to gelatin included in the varicella vaccine. J. Allergy Clin. Immonol. (1997) 99(2):263-264.
8. NARUSE H, MIWATA H, OZAKI T, ASANO Y, NAMAZUE J, YAMANISHI K: Varicella infection complicated with meningitis after immunization. Acta. Paediatr. Jpn. (1993) 35(4):345-347.
9. LEE SY, KOMP DM, ANDIMAN W: Thrombocytopenic Purpura following varicella-zoster vaccination. Am. J. Pediatr. Hematol. Oncol. (1986) 8(1):78-80.
10. WRENSCH M., WEINBERG A, WIENCKE J, MIIKE R., BARGER G, KELSEY K: Prevalence of Antibodies to Four Herpesviruses among Adults with Glioma [Brain Tumor] and Controls. Am. J. Epidem. (2001) 154(2):161-165.
* Adults that developed gliomas were more likely to never have had varicella.
11. NASERI A, GOOD WV, CUNNINGHAM ET JR: Herpes zoster virus sclerokeratitis and anterior uveitis in a child following varicella vaccination. Am. J. Ophthalmol. (2003) 135(3):415-417.
12. ESMAELI-GUTSTEIN B, WINKELMAN JZ: Uveitis associated with varicella virus vaccine. Am. J. Ophthalmol. (1999) 127(6):733-734.
13. MATSUBARA K, NIGAMI H, HARIGAYA H, BABA K: Herpes zoster in a normal child after varicella vaccination. Acta. Paediatr. Jpn. (1995) 37(5):648-650.
* Authors report that a healthy 5-year-old girl developed HZ in the dermatome supplied by the ophthalmic branch of the fifth cranial nerve 40 months after varicella vaccination.
14. HAMMERSCHLAG MR, GERSHON AA, STEINBERG SP, CLARKE L, GELB LD: Herpes zoster in an adult recipient of live attenuated varicella vaccine. J. Infect. Dis. (1989) 160(3):535-537.
15. Centers for Disease Control and Prevention (CDC), Morbidity and Mortality Weekly Report (MMWR), Prevention of Varicella Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP), May 28, 1999; 48(RR06):1-5.
Competing interests:
None declared
Competing interests: No competing interests
The editorial by Professor Breuer [1] should be commended for
highlighting this important issue.
Currently the Varicella Zoster Virus (VZV) vaccine is not recommended
for routine use in children. The editorial has suggested that there are
two other population groups suitable for VZV immunisation: school leavers
and non-immune health care workers. The usefulness of vaccine use in the
former remains controversial, and the latter group is the basis of the
editorial. However, I wish to suggest a third group that should be
actively targeted for VZV vaccination- non-immune women undergoing
infertility treatment or presenting for preconceptual counseling.
In the UK (and most other countries), this group of women routinely
undergoes screening and immunization for Rubella, but do not undergo a
similar preventative strategy for VZV. This represents a missed
opportunity to prevent primary maternal VZV infection (which complicates 3
in every 1000 pregnancies, and occurs in the 5-10% of the pregnant
population that are non-immune to VZV) and the consequent serious maternal
and fetal complications. Importantly, this approach has not being entirely
missed by the USA and some other European countries, where non-immune
women undergoing infertility treatment or presenting for preconceptual
counseling are currently offered VZV immunization [2].
A recent study in the New England Journal of Medicine showed that a
policy of universal vaccination of susceptible children and adults in the
USA since 1995 was responsible for a dramatic decline in the incidence
(90%) and mortality (66%) from VZV infection, and was safe [3]. This
study, along with information contained within this editorial [1], has
strengthened the call for VZV immunization of all non-immune women who are
planning a pregnancy, as is undertaken for Rubella.
References:
1. Breuer J. Varicella vaccination for healthcare workers. BMJ 2005;
330:433-434
2. Chickenpox in Pregnancy. RCOG Clinical Guideline No. 13. RCOG
Press, 2001. http://www.rcog.org.uk/resources/public/chickenpox_no13.pdf
3. Nguyen HQ, Jumaan AO, Seward JF. Decline in mortality due to
varicella after implementation of varicella vaccination in the United
States. N Engl J Med. 2005 Feb 3;352(5):450-8
Competing interests:
None declared
Competing interests: No competing interests
Varicella vaccination for health care workers - Actions speak louder than words
Editor – We were disappointed to read in the Editorial by Breuer that
there has been a poor response to the Chief Medical Officer’s (CMO)
instruction that susceptible health care workers should be immunised
against varicella.1
Despite some initial concerns concerning the possible transmission of
vaccine virus from staff to vulnerable patients, when a staff outbreak
almost led to the closure of our acute admissions ward in May 2004,
vaccine was offered to all those shown by antibody testing to be
susceptible to chickenpox. Since then we have immunised 105 individuals,
both staff and students, who have direct patient contact, of whom 57 (54%)
have completed the course. Only three adverse reactions have been
reported. One person had a varicella-like rash (from which vaccine virus
was recovered), one had localised injection-site pruritis, and one had
diarrhoea and vomiting within 24 hours of vaccination. Significantly no
one has declined the offer of immunisation. This may be a reflection of
the way in which it is offered.
Varicella vaccine needs to be wholeheartedly embraced by NHS trusts
especially as the NHS continues to recruit staff from areas of the world
where childhood varicella is less common and consequently adult
susceptibility is much higher. Indeed, 50% of cases of varicella in staff
at St George’s prior to vaccination were in people from India, the
Caribbean and the Philippines.2 We agree that the CMO was correct in
concluding that it is likely that the cost of administering vaccine to
staff will save money as well as preventing transmission to patients,
though a prospective study to demonstrate this has never been performed.
In order to address this deficiency we are currently undertaking a
questionnaire survey of immunised staff to assess its protective efficacy
after virus exposure.
1. Breuer J. Varicella vaccination for healthcare workers. BMJ 2005;
330: 433-434.
2. Devi R, Muir D, Rice P. Deaths from Chickenpox: Do not forget
healthcare workers. BMJ 2002; 324: 610.
Competing interests:
None declared
Competing interests: No competing interests