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Selective serotonin reuptake inhibitors

BMJ 2005; 330 doi: (Published 17 February 2005) Cite this as: BMJ 2005;330:420

Evidence base for older antidepressants is shaky too

  1. Joanna Moncrieff, senior lecturer (
  1. University College London, Department of Mental Health Sciences, London W1N 8AA

    EDITOR—In contrast to Geddes and Cipriani's assertion of a lack of clinical uncertainty about the efficacy of antidepressants,1 a careful look at the evidence shows that this may not be true, even of the tricylic antidepressants. Although many trials show tricylic antidepressants to be superior to placebo, many find no difference, including some of the largest and best …

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