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BMJ 2005; 330 doi: (Published 10 February 2005) Cite this as: BMJ 2005;330:330
  1. Harvey Marcovitch, BMJ syndication editor (

Apomorphine may relieve restless legs

Nine patients with severe restless legs syndrome were pretreated with domperidone for three days to mitigate side effects of apomorphine, which was given as an intravenous infusion. All patients responded with fewer movements and subjective improvement. These findings could be used as a test for the condition, the authors say, and transdermal or subcutaneous apomorphine might eventually prove therapeutic.

J Neurol Neurosurg Psychiatry 2005;76: 181-5

Can worms treat Crohn's disease?

Twenty nine patients with longstanding Crohn's disease refractory to standard treatments were given repeated doses of the ova of Trichuris suis (pig whipworm), prepared from pathogen-free animals. At week 24 of the open label trial, 21 were in remission and another two were improved, much better than any expected placebo response. None had ill effects. The explanation may be that helminths blunt Th1 responses, which are known to …

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