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Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies

BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.38308.477650.63 (Published 27 January 2005) Cite this as: BMJ 2005;330:223
  1. S Darby, professor of medical statistics (sarah.darby{at}ctsu.ox.ac.uk)1,
  2. D Hill, statistician1,
  3. A Auvinen, professor of epidemiology2,
  4. J M Barros-Dios, professor of epidemiology3,
  5. H Baysson, statistician4,
  6. F Bochicchio, senior researcher5,
  7. H Deo, statistician6,
  8. R Falk, principal scientist7,
  9. F Forastiere, professor of epidemiology8,
  10. M Hakama, professor of epidemiology9,
  11. I Heid, statistician10,
  12. L Kreienbrock, professor of statistics11,
  13. M Kreuzer, epidemiologist12,
  14. F Lagarde, statistician13,
  15. I Mäkeläinen, health physicist14,
  16. C Muirhead, statistician15,
  17. W Oberaigner, epidemiologist16,
  18. G Pershagen, professor of environmental medicine13,
  19. A Ruano-Ravina, professor of epidemiology3,
  20. E Ruosteenoja, scientist14,
  21. A Schaffrath Rosario, statistician10,
  22. M Tirmarche, epidemiologist4,
  23. L Tomáscaron;ek, statistician17,
  24. E Whitley, visiting lecturer in medical statistics18,
  25. H-E Wichmann, professor of epidemiology10,
  26. R Doll, emeritus professor of medicine1
  1. 1 Clinical Trials Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford OX2 6HE
  2. 2 School of Public Health, University of Tampere, Tampere, Finland
  3. 3 Area of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain
  4. 4 Institut de Radioprotection et de Sûreté Nucléaire, Direction de la Radioprotection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Fontenay-aux-Roses Cedex, France
  5. 5 Unit of Radioactivity and its Health Effects, Department of Technology and Health, Italian National Institute of Health, Rome, Italy
  6. 6 Department of Applied Statistics, University of Reading, Reading RG6 2AL
  7. 7 Swedish Radiation Protection Authority, SE-171 16, Stockholm, Sweden
  8. 8 Department of Epidemiology, Rome E Health Authority, Rome, Italy
  9. 9 Finnish Cancer Registry, Helsinki, Finland
  10. 10 Institute of Epidemiology, GSF Research Centre for Environment and Health, Neuherberg, Germany
  11. 11 Institute of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine, Hannover, Germany
  12. 12 Department of Radiation Protection and Health, Federal Office for Radiation Protection, Neuherberg, Germany
  13. 13 Institute of Environmental Medicine, Karolinska Institute, S-171 77, Stockholm, Sweden
  14. 14 STUK-Radiation and Nuclear Safety Authority, Helsinki, Finland
  15. 15 National Radiological Protection Board, Chilton, Didcot OX11 0RQ
  16. 16 Tumorregister Tirol, Innsbruck, Austria
  17. 17 Epidemiology Unit, National Radiation Protection Institute, Prague, Czech Republic
  18. 18 Department of Social Medicine, University of Bristol, Bristol BS8 2PR
  1. Correspondence to: S Darby
  • Accepted 2 November 2004

Abstract

Objective To determine the risk of lung cancer associated with exposure at home to the radioactive disintegration products of naturally occurring radon gas

Design Collaborative analysis of individual data from 13 case-control studies of residential radon and lung cancer.

Setting Nine European countries.

Subjects 7148 cases of lung cancer and 14 208 controls.

Main outcome measures Relative risks of lung cancer and radon gas concentrations in homes inhabited during the previous 5-34 years measured in becquerels (radon disintegrations per second) per cubic metre (Bq/m3) of household air.

Results The mean measured radon concentration in homes of people in the control group was 97 Bq/m3, with 11% measuring > 200 and 4% measuring > 400 Bq/m3. For cases of lung cancer the mean concentration was 104 Bq/m3. The risk of lung cancer increased by 8.4% (95% confidence interval 3.0% to 15.8%) per 100 Bq/m3 increase in measured radon (P = 0.0007). This corresponds to an increase of 16% (5% to 31%) per 100 Bq/m3 increase in usual radon—that is, after correction for the dilution caused by random uncertainties in measuring radon concentrations. The dose-response relation seemed to be linear with no threshold and remained significant (P = 0.04) in analyses limited to individuals from homes with measured radon < 200 Bq/m3. The proportionate excess risk did not differ significantly with study, age, sex, or smoking. In the absence of other causes of death, the absolute risks of lung cancer by age 75 years at usual radon concentrations of 0, 100, and 400 Bq/m3 would be about 0.4%, 0.5%, and 0.7%, respectively, for lifelong non-smokers, and about 25 times greater (10%, 12%, and 16%) for cigarette smokers.

Conclusions Collectively, though not separately, these studies show appreciable hazards from residential radon, particularly for smokers and recent ex-smokers, and indicate that it is responsible for about 2% of all deaths from cancer in Europe.

Footnotes

  • Contributors All authors were responsible for the design of this collaboration. The data for the component studies were the responsibilities of WO, LK, ASR, MK, HEW (Austria);. Czech Republic: LT (Czech Republic); AA, IM, MH (Finland nationwide); ER, IM, MH (Finland south); HB, MT (France); MK, ASR, IH, LK, HEW (Germany eastern); LK, MK, HEW (Germany western); FB, FF (Italy); GP, FL, RF (Sweden nationwide); FL, GP, RF (Sweden never smokers); GP (Sweden Stockholm); JMB-D, AR-R (Spain); SD, HD, DH, EW, RD (United Kingdom). CM coordinated the European Commission grant. DH, HD, EW, and SD collated the data for all studies in Oxford. The analysis was conducted and the report prepared by SD, DH, and RD with input from all other authors. SD, DH, and RD are guarantors.

  • Funding Cancer Research UK (grants to Clinical Trial Service Unit and Cancer Epidemiology Unit) and the European Commission (contract FIGH-CT1999-00008). The funding sources had no role in study design, data collection, data analysis, data interpretation, the writing of the report, or the decision to submit the paper for publication.

  • Competing interest None declared.

  • Ethical approval Appropriate ethical committee approval was obtained for each study.

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