Bmj Usa


BMJ 2004; 329 doi: (Published 09 December 2004) Cite this as: BMJ 2004;329:E333
  1. Godfrey Oakley Jr, research professor of epidemiology
  1. Rollins School of Public Health of Emory University 1518 Clifton Rd NE, Atlanta, GA 30322

Randomized controlled trials are not the usual way serious, uncommon adverse effects of a new drug are discovered. They are usually discovered in observational studies, often case-control studies. I think there is danger in using RCTs to find adverse effects. It would feed on the current vogue from trialists that the only data that count are those from RCTs. By this standard, we would …

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