Fillers POEM

SSRIs provide modest benefit in selected patients with IBS

BMJ 2004; 329 doi: (Published 11 November 2004) Cite this as: BMJ 2004;329:0-g

Question Are selective serotonin reuptake inhibitors effective for the treatment of irritable bowel syndrome (IBS)?

Synopsis Although tricyclic antidepressants are somewhat effective for irritable bowel syndrome, it is less clear whether selective serotonin reuptake inhibitors (SSRIs) are similarly helpful. Patients for this randomised controlled trial (double blinded) came from two groups: patients presenting to the gastroenterologist eating a low fibre diet who did not improve on a high fibre diet, and patients who were already eating a high fibre diet. They were randomised to either placebo (n = 43) or paroxetine 10 mg …

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