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Combination anticoagulation therapy doubles risk of bleeding in patients at high risk of stroke

BMJ 2004; 329 doi: (Published 29 July 2004) Cite this as: BMJ 2004;329:250
  1. Debashis Singh
  1. London

    Patients at high risk of stroke should not be treated with combination anticoagulation therapy using aspirin and clopidogrel—known to be beneficial for those with cardiovascular disease—because it doubles the risk of bleeding, concludes new research from the University of Essen, Germany (Lancet 2004;364:331-7).

    Previous research showed that clopidogrel was better than aspirin for patients who had recently had an ischaemic stroke, heart attack, or symptomatic peripheral arterial disease. Its benefits were greater in some high risk subgroups of patients, such as those with diabetes or previous …

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