Threatened miscarriage: evaluation and managementBMJ 2004; 329 doi: https://doi.org/10.1136/bmj.329.7458.152 (Published 15 July 2004) Cite this as: BMJ 2004;329:152
- Alexandros Sotiriadis (firstname.lastname@example.org), resident in obstetrics and gynaecology1,
- Stefania Papatheodorou, rural practitioner2,
- George Makrydimas, assistant professor of obstetrics and gynaecology1
- 1 Department of Obstetrics and Gynaecology, University Hospital of Ioannina, 45500 Ioannina, Greece
- 2 Delvinaki Health Centre, Delvinaki, Ioannina, Greece
- Correspondence to: A Sotiriadis
- Accepted 3 June 2004
Threatened miscarriage—vaginal bleeding before 20 gestational weeks—is the commonest complication in pregnancy, occurring in about a fifth of cases.w1 Miscarriage is 2.6 times as likely,1 and 17% of cases are expected to present complications later in pregnancy.2 Although general practitioners and gynaecologists often see this condition, management of threatened miscarriage is mostly empirical. Bed rest is routinely recommended, and about a third of women presenting with threatened miscarriage are prescribed drugs.w2 However, two thirds of the general practitioners recommending this do not believe it affects outcome.3
In this review, we present available evidence on the initial evaluation and management of threatened miscarriage, focusing mainly on the first trimester of pregnancy and primary healthcare settings.
Sources and selection
We searched literature in English with Medline (January 1965 to April 2004), Embase (January 1980 to April 2004), and the Cochrane database using the keywords “threatened” and “abortion” or “miscarriage” and “pregnancy” and “first trimester” or “early” and “bleeding”. We scanned abstracts and got the full text of relevant articles. We also scanned the references of retrieved articles. The more recent or randomised, prospective, or large studies focusing on women with symptoms of threatened miscarriage were primarily cited; we excluded studies on recurrent pregnancy loss or women without symptoms, unless otherwise stated.
Bleeding in the first trimester can originate from the uterus, cervix, or vagina, or it can be extragenital. Thorough physical examination is essential to differentiate between genital and extragenital causes. After exclusion of extragenital causes, several parameters have been associated with prognosis (table 1).
Older women are at increased risk of miscarriage in the general population.w3 A prospective study on women with threatened abortion reported that women older than 34 years had an odds ratio of 2.3 for miscarriage, however, …