Sulfadoxine-pyrimethamine for uncomplicated falciparum malaria: Sulfadoxine-pyrimethamine is not working in Malawi

BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7450.1259 (Published 20 May 2004) Cite this as: BMJ 2004;328:1259
  1. Nicholas White, professor of tropical medicine (nickw@tropmedres.ac)
  1. Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok 10400, Thailand

    EDITOR—The paper by Plowe et al entitled “Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria” might be better titled “Sustained lack of efficacy of sulfadoxine-pyrimethamine….”1 By the start of the study period five years ago, molecular genotyping showed that Plasmodium falciparum in Malawi had already acquired significant resistance to the combination.1 2 This explains the sustained lack of efficacy; …

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