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Lowering homocysteine did not prevent recurrent stroke

BMJ 2004; 328 doi: (Published 20 May 2004) Cite this as: BMJ 2004;328:0-g

Question Does lowering the homocysteine level in patients with ischaemic stroke prevent recurrent stroke?

Synopsis Observational studies have indicated that raised homocysteine levels are associated with an increased risk of recurrent stroke, acute coronary events, and mortality. Folic acid supplements have been suggested as a means to lower homocysteine levels and reduce these risks. Fifty six centres in the United States, Canada, and Scotland coordinated to enrol 3680 adults with non-disabling cerebral infarction. The patients received the best medical and surgical care and were …

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