If it doesn't work, stop itBMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7446.1015 (Published 22 April 2004) Cite this as: BMJ 2004;328:1015
“Ineffective” treatments might be in a patient's best interests
- Peter R Jackson, reader in clinical pharmacology and therapeutics (Peter.R.Jackson@shef.ac.uk)
- Royal Hallamshire Hospital, Sheffield S10 2JF
EDITOR—To have a themed issue (28 February) on negative trial results was innovative but risks returning to a dichotomous view of outcomes that should have been abandoned with hypothesis testing. Even means and confidence intervals ignore the wide range of responses likely to be experienced by individual patients.
Much of this variation probably represents measurement error or intraindividual variability, …