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Once daily valcyclovir slightly reduces the risk of transmitting HSV-2 to uninfected partners

BMJ 2004; 328 doi: (Published 25 March 2004) Cite this as: BMJ 2004;328:0-f

Question Does daily valcyclovir reduce the risk of transmission of herpes simplex virus-2 (HSV-2) to uninfected sexual partners?

Synopsis Although we know that antiviral drugs reduce the frequency of recurrence, and also reduce subclinical shedding of viral particles (a disease oriented outcome), no trial to date has demonstrated an effect on the transmission of HSV-2 infection to an uninfected partner. In this randomised controlled (double blinded) trial, 1498 couples in which one partner was HSV-2 …

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