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Hypothermia can indeed benefit those admitted with failure of
immediate neurological recovery after CPR and defibrillation. Another
intervention that could interrupt the process of inflammation and ischemic
reperfusion injury that is consequence of prolonged cardiac arrest, could
be the infusion of Glucose+Insuline+Potassium (GIK solution), known since
the studies of Demetrio Sodi-Pallares four decades ago.
GIK solution has gained a lot of renewed interest in the last decade,
after several studies have demonstrated its usefulness and cost-
effectiveness in the management of myocardial infarction, also in
combination with thrombolysis.
The last study from Ajay Chaudhuri et.al., this week in Circulation
(2004; 109: 849-854), confirms the reduction of inflammation using the GIK
solution combined with thrombolysis in patients with ST elevation acute