Intended for healthcare professionals

Clinical Review

Statistical aspects

BMJ 2004; 328 doi: (Published 26 February 2004) Cite this as: BMJ 2004;328:506
  1. Michael J Campbell, professor of medical statistics (
  1. 1 Institute of Primary Care, School of Health and Related Research, University of Sheffield, Northern General Hospital, Sheffield S5 7AU

    The main issue in this study is the use of an n of 1 trial for the evaluation of treatments for nausea and vomiting in pregnancy. These trials are used to decide what treatment benefits an individual patient and are a more scientific method of decision making than the usual method used by general practitioners: asking the patient to return if the first treatment doesn't work and trying a second one.1 As I have pointed out before, R A Fisher, one of the greatest statisticians, discussed at …

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