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Clinical Review Interactive case report

Treating nausea and vomiting during pregnancy: case progression

BMJ 2004; 328 doi: (Published 05 February 2004) Cite this as: BMJ 2004;328:337
  1. Nicola Harker, general practitioner1,
  2. Alan Montgomery, lecturer in primary care research2,
  3. Tom Fahey, professor of primary care medicine (
  1. 1Dean Lane Family Practice, Bedminster, Bristol
  2. 2Division of Primary Health Care, University of Bristol
  3. 3Tayside Centre for General Practice, University of Dundee, Dundee DD2 4AD
  1. Correspondence to: T Fahey

Last week (31 January, p 276) we presented the case of Ms Reynolds, a 25 year old woman who presented to her general practitioner when eight weeks pregnant complaining of nausea and vomiting with light headedness. After an unsuccessful trial of prochlorperazine, she asked about alternatives to conventional drugs. We invited responses on which therapeutic options are safe to consider or recommend in pregnancy, what study design might provide evidence for their relative efficacy in an individual patient, and what proportion of patients and pregnant women use complementary therapies. To look at the discussion of the case so far go to

One of us (NH) is interested in complementary medicine and suggested a trial of vitamin B-6 (pyridoxine) to relieve the patient's symptoms. We searched Medline (1996 onwards, limiting our search to review articles) using the …

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