Colchicine in acute goutBMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7434.288-d (Published 29 January 2004) Cite this as: BMJ 2004;328:288
Low dose colchicine was started after usual dose
- G Sivagnanam, additional professor of pharmacology ()
EDITOR—Morris et al emphasise that in acute gout lower doses of colchicine are effective yet less toxic than traditional regimens.1 Certain points need, however, to be considered.
In all the three cases quoted the patients initially started taking higher (traditional) doses of colchicine and only after they had experienced adverse effects were their doses reduced. This means a lingering effect of colchicine would be present. Evidence shows that colchicine will be present in leucocytes (site of action) for at least nine days after a single intravenous dose.2 To claim that a lower dose of colchicine is effective, should one not start with a lower dose?
Because toxicity is more common with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs, such as indomethacin or naproxen) are preferred.2 In one of the three cases mentioned, meloxicam was tried without benefit. Meloxicam is a drug with a long half life, and it needs time for steady state concentration to be achieved.
Colchicine has generally been replaced by less toxic drugs such as NSAIDs,3 4 and corticosteroids (preferably via intrasynovial injection)3 for relief of an acute attack. Colchicine should be reserved for patients in whom these other agents are contraindicated or ineffective.3 Although Morris et al claim that they do not advocate an increase in the use of colchicines, it seems that all other avenues were not exhausted. Colchicine has been reported to be equally effective, and the gastrointestinal side effects may be avoided almost completely if it is given intravenously.2
Competing interests None declared.