Intended for healthcare professionals

Fillers POEM

Donepezil is somewhat effective for Alzheimer's, probably better than galantamine

BMJ 2004; 328 doi: (Published 09 January 2004) Cite this as: BMJ 2004;328:0-g

Question Are cholinesterase inhibitors safe and effective for Alzheimer's dementia?

Synopsis A previous meta-analysis of functional and behavioural outcomes found little benefit to cholinesterase inhibitors in patients with Alzheimer's dementia JAMA 2003;289: 210-16). The current meta-analysis used “global response” as the primary outcome, defined as minimal improvement or better as evaluated by clinicians (clinical global impression of change scale) or clinicians and caregivers (clinician's interview-based impression of change plus caregiver input scale). A secondary outcome was “cognitive response,” defined as an improvement of four points or more on the Alzheimer's disease …

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