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Antiretroviral therapy increases risk of heart attack

BMJ 2003; 327 doi: (Published 20 November 2003) Cite this as: BMJ 2003;327:1186
  1. Scott Gottlieb
  1. New York

    Combination antiretroviral therapy was independently associated with a relative increase of about a quarter in the rate of myocardial infarction per year of exposure during the first four to six years of use. The absolute risk of myocardial infarction, however, was low and must be balanced against the marked benefits from antiretroviral treatment.

    In this prospective observational study, researchers from the Data Collection on Adverse Events of Anti-HIV Drugs Study Group enrolled 23 468 patients in Europe, the United States and Australia, from December 1999 to April 2001 and collected follow up data until February 2002. They collected data on infection with HIV …

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