Beyond doing
BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7425.0-h (Published 20 November 2003) Cite this as: BMJ 2003;327:0-hAll rapid responses
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Dear Sir,
siRNA, small interfering RNA, sounds like Picorna, pico-RNA-Virus,
interfering with microbes and host.
Common cold is the small RNA, interfering with streptococci and
tuberculosis.
HIV is the small RNA, interfering with tuberculosis.
This could be a unifying concept of host-microbe-interference:
Small RNA changes the susceptibility of the host.
People of cold regions, adapted to common cold, show a different
resistance to small RNA compared to people of hot regions, adapted to
malaria.
Sincerily Yours
Friedrich Flachsbart
Competing interests:
None declared
Competing interests: No competing interests
Challenge to Nature: Prove that 'HIV' exists via visual confirmation.
The Huw Christie Memorial Prize:
£100,000 Reward for 'HIV' isolation
Offered by Mr. Alexander Russell 28th November 2003
"...infectious units, after all, are the only clinically relevant
criteria for a viral pathogen."
Peter Duesberg and Harvey Bialy (Nature, 375, 1995, p. 197)
"The most formidable barrier to the advancement of science is the
conventional wisdom of the dominant group."
Geneticist C. H. Waddington
I am offering £100,000 Reward for the first paper published in Nature
magazine that can prove that 'HIV' isolation exists via visual
confirmation.
There is no evidence that 'HIV' is a sexually transmitted retrovirus
and the current 2002 UK Public Health Laboratory Service figures clearly
confirm this. You simply cannot have a putative retrovirus that is
permanently restricted for 20 years to the two originally identified risk
group: gay men and drug addicts in the West.
There is no heterosexual 'HIV/AIDS' epidemic in the UK, Europe and
the USA. In the Ukraine and Easter Europe this is not an 'AIDS' epidemic
but a recreational drug epidemic. It is the recreational drugs that are
the activating factors; that are activating the endogenous material
wrongly labelled 'HIV'. It is the chemicals in cocaine and other
recreational drugs that make people test 'HIV' positive and not the
putative 'HIV'.
Cocaine acts as an in vivo mitogen in exactly the same way that other
plant derived substances have a mitogenic effect on cell-cultures in
vitro. Indeed, experiments have shown that when cocaine is added to cell-
cultures, the cells are activated and show a typical mitogenic response.
Cocaine is the most obvious example but add to this the full repertoire of
recreational drugs indulged in by many gay men and it is no wonder that
their constantly activate cells permit the putative 'HIV' tests to dredge
up something endogenous. (I suggest people read the important new paper
by Peter Duesberg et al: The chemical bases of the various AIDS
epidemics: recreational drugs, anti-viral chemotherapy and malnutrition
(Journal of Bioscience, Vol. 28, No.4, June 2003, Indian Academy of
Sciences).
Hans Gelderblom of Berlin's Robert Koch Institute co-authored the
first paper in Virology, March 1997, showing 'purified HIV' to be
'purified microvesicles'. What was assumed to be 'purified HIV' was in
fact "an excess of vesicles" - particles of cellular proteins. The
hypothetical 'HIV' is in fact a collection of endogenous microvesicles and
cellular proteins (which also never seem to form particles - so how can
they be infectious)? Cell-free viral 'HIV' particles have never ever been
visualised in any freshly donated bodily fluid including semen, blood,
etc. 'HIV' has never ever proven to be a sexually transmitted retrovirus.
To date: no electron-micrograph image exists of isolated/purified densely
packed 'HIV' particles recovered directly from fresh samples of any bodily
fluid. The key fact to remember is that cell-free infectious 'HIV' viral
particles have never, repeat never, been recovered directly from fresh
donor semen, a blood sample or any other bodily fluid.
The rules demonstrating the existence of 'HIV' (and retroviruses in
general) were never adhered to by those who devised them nor were they
ever validated. No particle of 'HIV' has ever been obtained pure, free of
contaminants; nor has a complete piece of 'HIV RNA' (or the transcribed
DNA) ever been proved to exist.
So confident am I that no such electron-micrograph evidence for the
existence of 'HIV' can be produced by adhering strictly to the Etienne de
Harven methodology, I am prepared to offer the sum of £100,000 to the
first person to submit just such a micrograph, prepared under stringent
laboratory conditions. I do not want 'markers' for 'viral activity' which
are at very best, inaccurate. I want visual evidence of myriad active,
infectious viral particles, clearly morphologically defined recovered from
a fresh sample of bodily fluid, unadulterated with any other kinds of
cells: i.e: CEM,H9 cancer cells. As Peter Duesberg and Harvey Bialy stated
in Nature: "...infectious units, after all, are the only clinically
relevant criteria for a viral pathogen." (Nature, 375, 1995, p. 197) Once
again, to paraphrase Peter Duesberg, an alleged 'virus' which is not doing
anything cannot be 'causing' anything.
The rules for attempting to isolate the putative 'HIV' via the
Etienne de Harven methodology are:
1. Only plasma centrifuged from fresh whole blood may be used in the
experiment. No material derived from cultured cells will be considered, to
rule out 'viral particles' which may be merely cultural artefacts.
2. The donor blood/plasma must be taken from a person/persons with a
recent 'high-viral load' test result, and evidence for the date and result
of the test (the number of 'HIV'- RNA's alleged) must be submitted,
obviously with the name of the person/persons deleted to preserve donor
confidentiality.
3. The donor must not be in receipt of protease inhibitors, AZT or
any 'antiviral drugs'.
4. Only cold heparinised Ringer's solution may be used to dilute the
plasma 1/1 ( i.e. 50%).
5. The diluted plasma shall be first filtered by aspiration-
filtration, through a 0.6 millipore membrane. The resulting filtrate #1
will then be filtered again, this time using a 0.22 millipore membrane and
filtrate #2 will be submitted to ultracentrifugation.
6. Centrifugation at 30,000 g for two hours will be used to prepare a
pellet, likely to be extremely small. This pellet will be fixed with
glutaraldehyde and osmium, then carefully detached and embedded in epoxy
resins following routine EM procedures.
7. The electronmicrograph shall be at least 19,500 x magnification,
and must resemble that published in Fig.1 of this article for particle
size and shape, but with one notable and important variation. 'HIV' has
been deemed to be a lentivirus, possessing a dense core of truncated
conical shape. An ultrathin slice of randomly packed lentiviruses must
inevitably show a number of particles bisected to show this core
lengthwise, as well as end-on, with a resultant apparent mixture of round
and 'rod-shaped' dense cores. Any micrograph which does not clearly show
this feature will be deemed not to represent the lentivirus 'HIV'.
8. This challenge is open to any qualified scientists, or
microbiology students/lab technicians with the necessary lab skills and
facilities to carry out the work.
Photographs of the required electron-micrograph(s) plus full details
of the methodology, along with brief details of the senders'
qualifications, must be sent to me at: alex@lalage52.freeserve.co.uk
NB: Emeritus Professor of Pathology, University of Toronto. He worked
in electron microscopy primarily on the ultrastructure of retroviruses
throughout his professional career of 25 years at the Sloan Kettering
Institute in New York, and 13 years at the University of Toronto.
http://www.sidasante.com/edhindex.htm
Mr. Alexander Russell MA 28th November 2003
Competing interests:
None declared
Competing interests: No competing interests
Dear Sir,
"The BMJ is under fire from AIDS researchers over a series of
publications on its website." Nature/Vol 426/20 November 2003/page 215.
I am sure that Your open market place of medical opinions is
extremely useful.
Even Nature does not know everything.
Sometimes very small things become most exciting:
We only have to look on siRNA!
We have to have the whole picture.
We have to see the complexity of nature.
Every scientist is forced to focus.
Sometimes he lost the vision.
But we have to think and to think again before we do!
Sincerely Yours
Friedrich Flachsbart
Competing interests:
None declared
Competing interests: No competing interests
Free speech, changing concepts - BMJ in Nature, RNA in Nature
Dear Sir,
the letter in Nature, Vol. 427, 22 January 2004, page 287
by Richard Smith ("Milton and Galileo would back BMJ on free speech.
Arguments, crazy ideas and open communication are the LIFEBLOOD of
science") is mirrored by two articles in the same issue on "Viral entry
into host cells":
The classical concept of immunity, B-cells and T-cells, is not even
mentioned.
A complex concept of fusion proteins targeting the membrane emerges.
Life is a complex matter.
Free discussion of new concepts is life.
Sincerely Yours
Friedrich Flachsbart
Competing interests:
None declared
Competing interests: No competing interests