New angiotensin receptor blocker is as effective as ACE inhibitor

BMJ 2003; 327 doi: (Published 13 November 2003) Cite this as: BMJ 2003;327:1123
  1. Scott Gottlieb
  1. New York

    An angiotensin receptor blocker is as effective as an angiotensin converting enzyme (ACE) inhibitor in patients who are at high risk of cardiovascular events after myocardial infarction. But combining the two drugs seems to increase the rate of adverse events without improving survival.

    ACE inhibitors reduce mortality and cardiovascular morbidity among patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. In a double blind trial known as the Valiant study, researchers led by Dr Marc Pfeffer, professor of cardiology at the Brigham and …

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