Letters
Small risk ratios may have strong public health impact
BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7422.1050-c (Published 30 October 2003) Cite this as: BMJ 2003;327:1050
- Alfonso Carvajal (carvajal@ife.uva.es), professor of pharmacology,
- Miguel Angel Maciá, clinical pharmacologist,
- Javier García del Pozo, pharmacist,
- Francisco de Abajo, head
- Instituto de Farmacoepidemiología, Ramán y Cajal, 7, E-47005 Valladolid, Spain
- Pharmacovigilance Centre of Castilla-La Mancha, Toledo, Spain
- Spanish Medicines Agency, Madrid, Spain
EDITOR—Traversa et al studied the hepatoxicity of nimesulide and other nonsteroidal anti-inflammatory drugs (NSAIDs).1 Nimesulide may arguably have a small risk of the more severe hepatic injuries with an odds ratio of 1.9 (95% confidence interval 1.1 to 3.81). Since the drug is widely used in Italy the population attributable risk could account …
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