Intended for healthcare professionals


Small risk ratios may have strong public health impact

BMJ 2003; 327 doi: (Published 30 October 2003) Cite this as: BMJ 2003;327:1050
  1. Alfonso Carvajal (, professor of pharmacology,
  2. Miguel Angel Maciá, clinical pharmacologist,
  3. Javier García del Pozo, pharmacist,
  4. Francisco de Abajo, head
  1. Instituto de Farmacoepidemiología, Ramán y Cajal, 7, E-47005 Valladolid, Spain
  2. Pharmacovigilance Centre of Castilla-La Mancha, Toledo, Spain
  3. Spanish Medicines Agency, Madrid, Spain

    EDITOR—Traversa et al studied the hepatoxicity of nimesulide and other nonsteroidal anti-inflammatory drugs (NSAIDs).1 Nimesulide may arguably have a small risk of the more severe hepatic injuries with an odds ratio of 1.9 (95% confidence interval 1.1 to 3.81). Since the drug is widely used in Italy the population attributable risk could account …

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