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Experts regret early cessation of anticancer drug trial

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7420.885 (Published 16 October 2003) Cite this as: BMJ 2003;327:885
  1. Scott Gottlieb
  1. New York

    Treatment with the aromatase inhibitor letrozole after five years of tamoxifen treatment seems to improve disease-free survival in postmenopausal women with primary breast cancer.


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    Study participant Kathy Anderson (left) and second author of the research paper Dr James Ingle of the Mayo Clinic in Rochester, Minnesota (right)

    Credit: AP PHOTO/AARON HARRIS

    The study, designed to test five years of letrozole treatment after tamoxifen therapy, was discontinued after a median follow up of only 2.4 years because the researchers observed survival benefit in the letrozole group compared with the placebo group. The study is scheduled to …

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