Balancing benefits and harms in health care:

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7417.750-a (Published 25 September 2003) Cite this as: BMJ 2003;327:750

Observational data on harm should complement systematic reviews of benefit

  1. Jan P Vandenbroucke (j.p.vandenbroucke@lumc.nl), professor of clinical epidemiology
  1. Leiden University Medical Centre, PO Box 9600, NL-2300 RC Leiden, Netherlands

    EDITOR–The meeting on “rare events” mentioned by Cuervo and Clarke was an opportunity to bridge two worlds: the world of systematic reviews of randomised trials, which investigate benefits of treatment, and the world of pharmacoepidemiology, which mainly investigates the harms of the same treatments.1 …

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