Intended for healthcare professionals

Clinical Review ABC of subfertility

Tubal subfertility

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7415.610 (Published 11 September 2003) Cite this as: BMJ 2003;327:610
  1. Yacoub Khalaf

    Introduction

    Patent fallopian tubes are a prerequisite for normal human fertility. However, patency alone is not enough—normal function is crucial. Although patients often view them as either open or “blocked,” the fallopian tubes are highly specialised organs. They have a critical role in picking up eggs and transporting eggs, sperm, and the embryo. The fallopian tubes are also needed for sperm capacitation and egg fertilisation. Because the egg is fertilised in the fallopian tubes and the first stages of development of the embryo occur during its four day journey to the uterine cavity, the tubes are also important in nutrition and development. The fallopian tubes are vulnerable to infection and surgical damage, which may impair function by affecting the delicate fimbriae or the highly specialised endosalpinx. A fallopian tube obstruction occurs in 12% to 33% of infertile couples,1 and so tubal patency should be investigated early.

    Causes of tubal damage

    Infection

    Pelvic infection is a major cause of tubal subfertility. Infective tubal damage can be caused by sexually transmitted diseases, or can occur after miscarriage, termination of pregnancy, puerperal sepsis, or insertion of an intrauterine contraceptive device. The severity of tubal subfertility after pelvic infection depends on the number and severity of episodes.2 Although a history of symptomatic pelvic inflammatory disease may heighten suspicion of tubal damage, most women with tubal infertility do not report it. Even in women with serological evidence of past chlamydial or gonococcal infections, most are unaware of the infection.

    Figure1

    Incidence of tubal occlusion after pelvic infection

    Chlamydia trachomatis

    Chlamydia trachomatis accounts for around half the cases of acute pelvic inflammatory disease in developed countries. It is the commonest sexually transmitted agent in the United Kingdom. Chlamydial infections are often not diagnosed because they are usually asymptomatic or have few signs of infection. Both symptomatic and asymptomatic chlamydial infections can damage the reproductive tract. In women, they can cause urethritis, cervicitis, endometritis, and salpingitis, which may result in peritubal adhesions. These adhesions may cause subfertility, ectopic pregnancy, and chronic pelvic pain. Delayed treatment increases the risk of these sequelae and transmission of the infection to sexual partners.

    Gonorrhoea

    Gonorrhoea is particularly common in young, urban women of low socioeconomic groups and in people who have several sexual partners. It may present as a localised infection of the lower genital tract, as an invasive infection of the upper genital tract, or as disseminated disease with systemic manifestations; however, it may be asymptomatic. Infection with chlamydia is concurrent in 30-50% of patients from whom gonococcus is isolated.


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    Perihepatic adhesions (arrow) seen at laparoscopy usually associated with pelvic gonorrhoeal or chlamydial infection (Fitz-Hugh-Curtis syndrome)

    Genital tuberculosis

    Genital tuberculosis can cause simple tubal block, tubo-ovarian abscesses, or dense pelvic adhesions (frozen pelvis).

    Incidence of tubal occlusion rises with the number of pelvic infections the patient has had

    Genital tuberculosis is more common in UK inner city areas with increasing immigrant populations

    Post-pregnancy sepsis

    Post-pregnancy sepsis (post-abortion and puerperal infection) may be associated with salpingitis and endometritis. Endometritis with retained products of pregnancy followed by vigorous curettage can result in denudation of the endometrium; intrauterine adhesions (synechiae) can form, which may wholly or partially occlude the uterine cavity. This is an unusual, but important, cause of infertility (Asherman's syndrome), and the patient generally presents with oligomenorrhoea or amenorrhoea, although the hormone profile of the patient is normal.


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    Hysterosalpingogram showing contrast filling defects caused by intrauterine adhesions. The arrows show the areas of front to back adhesion partially occluding the cavity and disrupting the normal endometrium

    Intrauterine contraceptive devices

    Upper genital tract infection associated with intrauterine contraceptive devices is temporally linked to the insertion of the device. Increased risk occurs in the first 20 days after insertion. Beyond the first month after insertion the risk of upper genital tract infection is small. The risk of infertility after the use of an intrauterine contraceptive device is stopped is not increased, nor is fertility impaired even when the device is removed (usually because of complications, such as menorrhagia).

    Endometriosis

    Complete tubal occlusion is rarely caused by pelvic endometriosis. Tubal distortion and limitation of fimbrial mobility caused by the associated pelvic adhesions is more likely.

    Surgery

    Complications after surgery

    Previous laparotomy is a recognised risk factor for tubal subfertility, but a history of perforated appendix in childhood does not seem to have a long term negative effect on female fertility.


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    Laparoscopy showing two Filshie clips on the right fallopian tube. Double application has no benefit as it is no more effective and destroys a greater length of tube, making reversal less likely to be successful

    Sterilisation

    People who change their mind after tubal interruption and wish to conceive can have surgical reconstruction of the fallopian tubes or in vitro fertilisation. The results of surgical reversal will depend on the method used to perform the sterilisation (clips, rings, diathermy, or excision), the site of sterilisation, the length of tube remaining, and ovulatory and sperm factor.

    Prevention of tubal damage

    Practising safe sex is important in reducing sexually transmitted diseases and their sequelae. Screening women of reproductive age for chlamydial infection has been shown to reduce its prevalence and the incidence of pelvic inflammatory disease. Aggressive treatment of suspected pelvic inflammatory disease reduces late sequelae.3

    The sexual partners of patients must be treated rapidly to decrease the risk of reinfection. The management of women undergoing induced abortion should include a strategy for minimising the risk of post-abortion pelvic inflammatory disease. Women undergoing invasive uterine procedures (hysteroscopy, hysterosalpingo-contrast sonography, and hysterosalpingography) should be screened for chlamydia or receive prophylactic antibiotics.

    Diagnosis of tubal subfertility

    Infection screening

    Chlamydia antibody testing is a simple and cheap screening test for the likelihood of tubal subfertility. The predictive value of testing will depend on the cut-off level of the immunoglobulin G titre chosen and the criteria applied for tubal factor subfertility. Recent studies concluded that the optimum cut-off titre should be 16 because it gives the best combination of sensitivity and specificity. However, high titres of chlamydial antibodies in infertile women indicate the need for early laparoscopy to assess tubal status.

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    The 31st Royal College of Obstetricians and Gynaecologists StudyGroup on the Prevention of Pelvic Infection recommended that non-pregnant women under 35 years undergoing uterine instrumentation (for example, intrauterine contraceptive device insertion, infertility laparoscopy, hysteroscopy, or endometrial sampling) should be screened for relevant organisms using a sensitive technique before the procedure, or failing that, should receive appropriateprophylactic antibiotics

    Hysterosalpingo-contrast sonography

    Hysterosalpingo-contrast sonography is a simple outpatient procedure using ultrasonography. An echocontrast fluid is introduced into the uterine cavity via a 5 French cervical balloon catheter so that the uterine cavity, ovaries, and fallopian tube patency can be assessed accurately. The use of transvaginal ultrasonography avoids exposure to x rays and is particularly suitable as a diagnostic test in patients with a low likelihood of tubal disease. Finding a normal cavity and bilateral fill and spill of contrast is reassuring, but where there is doubt, hysterosalpingography or a laparoscopy and dye hydrotubation test should be done. Transvaginal ultrasonography can sometimes be useful in detecting hydrosalpinges.


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    A dilated hydrosalpinx diagnosed by sonohysterography. The sausage shaped, dark hydosalpinx (filled with saline) stands out clearly against background structures

    Hysterosalpingography

    Hysterosalpingography is a simple, safe, and inexpensive x ray based contrast study of the uterine cavity and the fallopian tubes with a 65% sensitivity and 83% specificity for detecting tubal blockage.


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    Hysterosonogram showing an intracavity fibroid outlined by ultrasonic contrast medium

    Proximal tubal occlusion can be associated with mild peritoneal endometriosis. The mechanism is unclear, but the occlusion is thought to be caused by a combination of the deposition of intraluminal debris from retrograde menstruation and raised tubal perfusion pressure.4

    Distal tubal blockage, which is commonly caused by pelvic inflammatory disease, is usually associated with distension of the ampullary portion of the fallopian tube (hydrosalpinges) and variable degree of loss of the internal mucosal folds.


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    Hysterosalpinogram showing bilateral hydrosalpinges filled with x ray contrast that has been instilled via the cervix. The Cusco speculum blades and the thread of the metal cannula are seen at the base of the picture

    Laparoscopy and dye hydrotubation test

    A laparoscopy and dye hydrotubation (“lap and dye”) test is the most reliable, albeit expensive, tool used to diagnose tubal subfertility. It is usually performed as a day case surgical procedure under general anaesthesia. When there is no prior information about the uterine cavity, the test can be combined with hysteroscopy for maximum information. Morphological abnormalities of the fallopian tubes can be seen directly, and the general pelvic appearance may give some clue as to the likely cause of any abnormalities found. When comparing hysterosalpingography with laparoscopy, keep in mind that both procedures provide more information than on the condition of the fallopian tubes alone. Hysterosalpingography provides information about the status of the uterine cavity, whereas laparoscopy allows inspection of the intra-abdominal cavity, excludes peritoneal disease, and allows laparoscopic surgery. The latter has become especially important because it was recently shown that laparoscopic treatment of early endometriosis improves fertility prospects by 13% over the next nine months.

    Comparison of hysterosalpingography with laparoscopy

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    An expert advisory group of the chief medical officer for Englandsupported opportunistic screening for chlamydia in sexually active women under 25 years, and in older women who have a new sexual partner or have had two or morepartners in the past year

    Management options

    “Expectant” management

    Patients with tubal subfertility still have a chance (albeit reduced) of natural conception, but this will depend on the extent of the damage. Patients with severe tubal disease can become pregnant while they are on waiting lists for in vitro fertilisation. However, treatment with in vitro fertilisation or tubal surgery is more effective than “expectant” management.

    Transcervical tubal cannulation

    Transcervical tubal cannulation is an outpatient procedure indicated in cases of proximal occlusion. In 80-90% of cases it is successful in restoring the patency of at least one fallopian tube. About 30% of patients get pregnant in the first three to six months after the procedure.5 Because of its simplicity, transcervical tubal cannulation should be considered as a first line treatment for patients with proximal occlusion.


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    X ray film of a patent fallopian tube after transcervical tubal cannulation. The selective salpingography cannula points at the right cornu and contrast spills through into the pelvis

    Surgery

    Surgical treatment and its outcome are related to the site and extent of tubal damage. Reversal of tubal ligation is one of the main indications for tubal microsurgery. Laparoscopic adhesiolysis has the best results if the adhesions are the only factor responsible for subfertility. Distal tubal occlusion may be treated using a laser or more traditional instruments to open the phimosed fimbrial end. Where the tubes are irreversibly damaged and there are large, communicating hydrosalpinges, salpingectomy (laparoscopic or open) is recommended as the success of in vitro fertilisation is impaired by their presence.

    In vitro fertilisation

    As in vitro fertilisation can achieve a higher chance of pregnancy for all types of tubal subfertility, it should be regarded as effective treatment. Couples should be referred early because in vitro fertilisation success is strongly related to age. However, about 20% of pregnancies resulting from in vitro fertilisation are multiple pregnancies, with attendant risks and complications.

    Main issues in tubal subfertility

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    Yacoub Khalaf is a consultant gynaecologist and subspecialist in reproductive medicine at Guy's and St Thomas's NHS Hospital Trust, and consultant in the Guy's and St Thomas's assisted conception unit.

    The ABC of subfertility is edited by Peter Braude, professor and head of department of women's health, Guy's, King's, and St Thomas's School of Medicine, London, and Alison Taylor, consultant in reproductive medicine and director of the Guy's and St Thomas's assisted conception unit. The series will be published as a book in the winter.

    Footnotes

    • Competing interests None declared.

    References

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