Case fatality rates for meningococcal disease in an English population, 1963-98: database study
BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7415.596 (Published 11 September 2003) Cite this as: BMJ 2003;327:596Data supplement
Table A Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged under 15 years, 1963-98
Time period Cases admitted to hospital All cases No of cases No of deaths Case fatality rate (95% CI) No of cases Incidence per 100 000 population (95% CI) No of deaths† Case fatality rate (95% CI) 1963-68 28 2 7.1 (0.0 to 16.7) 29 3.5 (2.3 to 4.8) 3 10.3 (0.0 to 21.4) 1969-73 54 3 5.6 (0.0 to 11.7) 55 5.2 (3.8 to 6.6) 4 7.3 (0.4 to 14.1) 1974-78 67 5 7.5 (1.2 to 13.8) 68 3.2 (2.5 to 4.0) 6 8.8 (2.1 to 15.6) 1979-83 75 6 8.0 (1.9 to 14.1) 75 3.4 (2.6 to 4.2) 6 8.0 (1.9 to 14.1) 1984-88 100 11 11.0 (4.9 to 17.1) 104 4.6 (3.7 to 5.5) 15 14.4 (7.7 to 21.2) 1989-93 179 13 7.3 (3.5 to 11.1) 181 7.1 (6.0 to 8.1) 15 8.3 (4.3 to 12.3) 1994-98 276 16 5.8 (3.0 to 8.6) 278 10.4 (9.2 to 11.7) 18 6.5 (3.6 to 9.4) 1963-98 779 56 7.2 (5.4 to 9.0) 790 5.8 (5.4 to 6.2) 67 8.5 (6.5 to 10.4) P value for trend‡ 0.49 <0.001 0.28 *International Classification of Diseases, 9th revision code 036 and 10th revision code A39.
†Includes 11 people who died outside hospital or who had no record of hospital admission.
‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.36) and a significant increase 1989-98 (P<0.001).
Table B Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged 15-24 years, 1963-98
Time period Cases admitted to hospital All cases No of cases No of deaths Case fatality rate (95% CI) No of cases Incidence per 100 000 population (95% CI) No of deaths † Case fatality rate (95% CI) 1963-68 4 0 0 4 0.7 (0.0 to 1.4) 0 0 1969-73 9 1 11.1 (0.0 to 31.6) 9 1.2 (0.4 to 2.0) 1 11.1 (0.0 to 31.6) 1974-78 15 0 0 15 1.1 (0.5 to 1.6) 0 0 1979-83 18 3 16.7 (0.0 to 33.9) 18 1.0 (0.5 to 1.5) 3 16.7 (0.0 to 33.9) 1984-88 31 2 6.5 (0.0 to 15.1) 32 1.6 (1.0 to 2.2) 3 9.4 (0.0 to 19.5) 1989-93 66 8 12.1 (4.2 to 20.0) 68 3.5 (2.7 to 4.4) 10 14.7 (6.3 to 23.1) 1994-98 97 9 9.3 (3.5 to 15.1) 98 5.7 (4.6 to 6.9) 10 10.2 (4.2 to 16.2) 1963-98 240 23 9.6 (5.9 to 13.3) 244 2.4 (2.1 to 2.7) 27 11.1 (7.1 to 15.0) P value for trend‡ 0.61 <0.001 0.51 *International Classification of Diseases, 9th revision, code 036 and 10th revision code A39.
†Includes 4 people who died outside hospital or who had no record of hospital admission.
‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.94) and a significant increase 1989-98 (P<0.001).
Table C Cases of meningococcal disease* from the Oxford record linkage study database, number of deaths within 30 days and case fatality rate per 100 000: people aged at least 25 years, 1963-98
Cases admitted to hospital All cases Time period No of cases No of deaths Case fatality rate (95% CI) No of cases Incidence per 100 000 population (95% CI) No of deaths† Case fatality rate (95% CI) 1963-68 9 3 33.3 (2.5 to 64.1) 9 0.4 (0.2 to 0.7) 3 33.3 (2.5 to 64.1) 1969-73 7 1 14.3 (0.0 to 40.2) 8 0.3 (0.1 to 0.5) 2 25.0 (0.0 to 55.0) 1974-78 26 7 26.9 (9.9 to 44.0) 28 0.5 (0.3 to 0.7) 9 32.1 (14.8 to 49.4) 1979-83 20 2 10.0 (0.0 to 23.1) 20 0.3 (0.2 to 0.5) 2 10.0 (0.0 to 23.1) 1984-88 16 3 18.8 (0.0 to 37.9) 16 0.2 (0.1 to 0.3) 3 18.8 (0.0 to 37.9) 1989-93 58 4 6.9 (0.4 to 13.4) 59 0.7 (0.5 to 0.9) 5 8.5 (1.4 to 15.6) 1994-98 91 16 17.6 (9.8 to 25.4) 97 1.1 (0.9 to 1.3) 22 22.7 (14.3 to 31.0) 1963-98 227 36 15.9 (11.1 to 20.6) 237 0.6 (0.5 to 0.7) 47 19.8 (14.8 to 24.9) P value for trend‡ 0.18 <0.001 0.28 *International Classification of Diseases, 9th revision, code 036 and 10th revision code A39.
†Includes 10 people who died outside hospital or who had no record of hospital admission.
‡P values refer to the change in annual rates 1963-98 from logistic regression modelling. Visual inspection of the annual incidence rates and further modelling show little change in incidence 1963-88 (P=0.54) and a significant increase 1989-98 (P<0.001).
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