Antidepressant prescribing and suicide

BMJ 2003; 327 doi: https://doi.org/10.1136/bmj.327.7409.289 (Published 31 July 2003) Cite this as: BMJ 2003;327:289

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Authors' reply

  1. Wayne D Hall, professor,
  2. Andrea Mant, associate professor (a.mant@unsw.edu.au),
  3. Phillip B Mitchell, professor
  1. Office of Public Policy and Ethics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
  2. School of Public Health and Community Medicine, University of New South Wales, Sydney Hospital, PO Box 1614, Sydney, New South Wales 2001, Australia
  3. School of Psychiatry, University of New South Wales, Randwick, New South Wales 2031, Australia

    EDITOR—Our critical finding was the relation between decline in suicide rate and exposure to antidepressants across age groups in both sexes. We agree that time series data must be interpreted cautiously; that is why we considered alternative explanations.

    We disagree with Moncrieff that we should have used ratios of daily dependent doses. This would have been an alternative measure of change in exposure but not of overall antidepressant exposure. We agree that the daily dependent doses will underestimate prescribing levels of tricyclic …

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