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Student Education

Ophthalmology: ocular manifestations of systemic disease

BMJ 2003; 326 doi: https://doi.org/10.1136/sbmj.030498 (Published 01 April 2003) Cite this as: BMJ 2003;326:030498
  1. Sophia Pathai, senior house officer1,
  2. Andrew McNaught, consultant ophthalmic surgeon2
  1. 1West London Ophthalmology Rotation
  2. 2Gloucester Eye Unit, Cheltenham General Hospital

In the sixth and final article in our series, Sophia Pathai and Andrew McNaught highlight some diseases and drugs that can affect the eye

The saying that the eyes are the window to the soul is more than purely metaphorical; a variety of systemic disorders are associated with eye conditions that are either direct or indirect manifestations of the underlying disease process. On the ward, this scenario may present in two ways: the patient may be known to have a general condition such as diabetes, and is concurrently suffering from a related eye problem. Alternatively, and more rarely, a presenting eye problem may be the first indication of underlying systemic disease. It's worth being aware of ophthalmic conditions that are associated with generalised disorders as you will be alerted to look out for some of the potentially serious eye complications when looking after these patients on the general wards. And maybe occasionally, you will be able to dazzle your colleagues by diagnosing a systemic condition based on your examination of the eye.

Diabetes and the eye

Diabetes can have a whole host of complications affecting the eye. Starting from the outside in, the eyelids can be affected by styes and lid cellulitis due to the increased susceptibility to infection. Moving on to the lens, the prevalence of cataract is higher in diabetics, and they tend to develop at an earlier age.

Microvascular disease can affect the vascular supply to the extraocular muscles, which can lead to a muscle palsy usually manifest as diplopia. The palsy usually resolves of its own accord within 4-6 weeks. Beware of assuming that diabetic microvascular disease is responsible for an acute IIIrd nerve palsy in a diabetic. Generally, vasculopathic IIIrd nerve palsies are pupil sparing, whereas compressive lesions (for example, posterior communicating artery aneurysm) have pupillary involvement. However, this …

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