Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
BMJ 2003; 326 doi: https://doi.org/10.1136/bmj.326.7404.1427 (Published 26 June 2003) Cite this as: BMJ 2003;326:1427
Data supplement
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Web table A Average changes (95% confidence intervals) in persons taking thiazides, according to dose, in serum concentrations of total cholesterol and its low (LDL), high (HDL) and very low (VLDL) density lipoprotein subfractions, potassium, glucose, uric acid, adjusted for changes in the placebo groups, in randomised trials of thiazides
Web table A Average changes (95% confidence intervals) in persons taking thiazides, according to dose, in serum concentrations of total cholesterol and its low (LDL), high (HDL) and very low (VLDL) density lipoprotein subfractions, potassium, glucose, uric acid, adjusted for changes in the placebo groups, in randomised trials of thiazides
Dose of thiazide:
Half-standard dose
Standard dose
Twice-standard dose
No of
trials*
Average change
(mmol/l)
change as
% of mean
Average change
(mmol/l)
change as
% of mean
Average change
(mmol/l)
change as
% of mean
Cholesterol:
13
total
0.06 (-0.04 to 0.17)†
1%
0.18 (0.10 to 0.27)
3%
0.30 (0.14 to 0.47)
5%
LDL
-0.09 (-0.28 to 0.11)†
-2%
-0.04 (-0.02 to 0.13)†
-1%
0.01 (-0.23 to 0.26)†
1%
HDL
-0.03 (-0.08 to 0.03)†
-2%
-0.004 (-0.01 to 0.02)†
0%
0.03 (-0.01 to 0.08)†
3%
VLDL
0.07 (-0.09 to 0.23)†
12%
0.13 (0.03 to 0.23)
22%
0.19 (0.09 to 0.29)
32%
Potassium
27
-0.21 (-0.28 to -0.14)
-6%
-0.38 (-0.44 to -0.33)
-9%
-0.55 (-0.64 to -0.46)
-13%
Glucose
15
0.06 (0.00 to 0.12)
1%
0.19 (0.10 to 0.27)
3%
0.31 (0.18 to 0.45)
5%
Uric acid
20
0.032 (0.027 to 0.037)
9%
0.048 (0.043 to 0.053)
15%
0.064 (0.054 to 0.074)
21%
† Not statistically significant; however upper confidence interval is informative
* Reference numbers:
Cholesterol fractions: w2,w22,w28,w31,w33,w36,w44,w47-50,w56,w57
Potassium: w4,w25-41,w47-52,w56,w61,w63.
Glucose: w2,w28,w31-38,w47-50,w56
Uric acid: w9,w29-40,w47-51,w56,w63
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- Authors' reply
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- Managing hypertension in patients with type 2 diabetes mellitus.
- ASHP Therapeutic Position Statement on the Treatment of Hypertension.
- Secondary-prevention drug prescription in the very elderly after ischemic stroke or TIA
- Antihypertensive Medication Use Among US Adults With Hypertension
- Headaches and the Treatment of Blood Pressure: Results From a Meta-Analysis of 94 Randomized Placebo-Controlled Trials With 24 000 Participants
- Applying the 2005 Canadian Hypertension Education Program recommendations: 4. Managing uncomplicated hypertension
- Antihypertensive Medications Prescribed at Discharge After an Acute Ischemic Cerebrovascular Event
- "Polypill" for Cardiovascular Disease Prevention