Ethnographic study of incidence and severity of intravenous drug errors
BMJ 2003; 326 doi: https://doi.org/10.1136/bmj.326.7391.684 (Published 29 March 2003) Cite this as: BMJ 2003;326:684
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On the subject of bolus doses from IMED infusion devices, if Phillip
is referring to the Gemini models then the secondary infusion rate is not
a bolus dose system at all and such confusion can lead to further
problems.
The use of the secondary infusion rate assumes both a separate fluid
container and giving set attached to the primary administration set. In
the absence of a second giving set the fluid will be taken from the
primary container reducing the volume available to be infused without
decrementing the volume to be infused display.
Multiple bolus doses can significantly reduce the actual volume without
reducing the amount the pump will attempt to infuse so that the container
can empty (apparently) prematurely leading to problems such as air in the
line and discontinuity of infusion while a new fluid container and giving
set are prepared.
Such delays with critical infusions were identified in the original
article as potentially serious.
Of the volumetric infusion pumps in use at this hospital none are able to
deliver a true bolus though several have secondary infusion rates that are
used as such by staff. I have no information about how many errors have
occurred as a result of this but I feel that only if there were an extreme
deterioration of the patient’s condition would anything be reported.
Competing interests:
Trying to teach too many pumps to too many nurses
Competing interests: No competing interests
The recent study by Taxis and Barber (1) reports that two out of
three potentially severe errors were preparation errors of continuous
infusion drugs. Dosage of continuous infused medications can be
complicated and time-consuming. Standard solutions, equations (2,3) and
even graphics (4) are published to make easier calculations. But, not one
works in a universal way. A formula, ready to use in all ages and any
clinical status, is: D/RxVxW/QxCxK where D is dose in mg/kg/h or IU/kg/h,
R is rate in ml/h, V is volume of solution in ml, W is patient’s weight
in kg, Q is the quantity of drug in the container in mg or IU, C is volume
of container (ampoule or bottle) in ml, and K is a constant with two
possible values: 1 in case of dose given in mg/kg/h or IU/kg/h, and 0.06
in case of dose given in mcg/kg/min to convert it to mg/kg/h (60 min
divided by 1000 mcg). The result is the amount of fluid to take out of
container to prepare the patient’s solution.
A equation with seven variables is difficult to remember, but can be
easier to hold in mind with all consonants less "y" of two words:
"DRiVeWay QuiCK".
Perhaps this one-step equation lessens the errors using continuous
infusion medications.
1. Taxis K, Barber N. Ethnographic study of incidence and severity of
intravenous drug errors. BMJ 2003;326:684-7.
2. Chernow B (Ed). The pharmacologic approach to the critical ill patient.
Third Edition. Baltimore, Williams & Wilkins. 1994.
3. Young TE, Mangum B (Eds): Neofax: A manual of drugs used in neonatal
care. Fourteenth Edition. Raleigh, Acorn Publishing, 2001.
4. Lamiell JM, Wallis JG. Computer-generated drug-dosing nomograms. Crit
Care Med 1988; 16:1246-7.
Competing interests:
None declared
Competing interests: No competing interests
Editor,
Can there be a “system” of drug administration independent of
cultural considerations?
I read the study cited[1] in the response by Anton et al., and though
it’s not mentioned in the response, I wasn’t surprised to find the authors
of the cited study noting the higher rates of arithmetic error in drug
calculations and drug mixing among their study participants in clinical
settings, compared to industrial arithmetic error rates with “self-
checking”.
Administrators should endorse attitudes which allow nurses to do
their work without the excess and paranoia of checking each others every
move and utterance. Studying nurses who are already busy studying each
other, is madness. Educating nurses to “tertiary” standard, only to
systematically deskill them in an out of date hospital culture of
cloistered “sisterhood” which seems preoccupied with bedpan rinsing, and
call bell answering, and baby-feeding, is counterproductive.
Phillip J. Colquitt, New Farm, Qld., Australia
PS. Please feel free to comment on errors.
[1] Ferner RE, Langford NJ, Anton C, Hutchings A, Bateman DN,
Routledge PA. Random and systematic medication errors in routine clinical
practice: a multicentre study of infusions, using acetylcysteine as an
example. British Journal of Clinical Pharmacology 2001; 52: 573-7.
Competing interests:
Education
Competing interests: No competing interests
As Taxis and Barber report, (1) there are few prospective studies
into the incidence of errors in intravenous administration of drugs.
There are problems in devising such studies because the very act of being
observed may alter behaviour and introduce bias the Hawthorn effect;
and because some errors inevitably escape detection. Observational studies
such as those of Taxis and Barber can therefore underestimate the
incidence of medication errors. We and our colleagues in three other
centres assessed errors in the administration of acetylcysteine used to
treat paracetamol poisoning by measuring the concentration of drug in the
infusate. (2) The regimen is complex, and each patient receives three
infusion bags, each of a different volume, and containing a dose of
acetylcysteine adjusted by patient weight. (3)
We had expected that most of the bags would contain within 10% of the
intended dose, but this was true in only 66 of 184 bags (36%); and in 17
bags (9%) the actual concentration differed from that which was intended
by more than 50%.
Taxis and Barber suggest that centralised preparation in the pharmacy
department might reduce infusion errors. Pharmacists prepared infusions in
one of our centres (centre C). Results were similar to those in two of the
other three centres, suggesting that there are difficulties even when
pharmacists are responsible (see Figure). Potentially serious dosing
errors will persist until better systems are devised for the whole process
of prescribing, making up, and giving medicines.
References
1. Taxis K, Barber N. Ethnographic study of incidence and severity of
intravenous drug errors. British Medical Journal 2003; 326: 684-7.
2. Ferner RE, Langford NJ, Anton C, Hutchings A, Bateman DN,
Routledge PA. Random and systematic medication errors in routine clinical
practice: a multicentre study of infusions, using acetylcysteine as an
example. British Journal of Clinical Pharmacology 2001; 52: 573-7.
3. British Medical Association, Royal Pharmaceutical Society of Great
Britain. British National Formulary 44. Wallingford: Pharmaceutical Press,
2002: 24.
Competing interests:
None declared
Competing interests: No competing interests
As researchers who specialise in qualitative methodologies we read
with great interest the recent study by Katja Taxis and Nick Barber (BMJ,
326, pp684-687). Whilst we appreciate the attempts of the authors to shed
some light on the nature of intravenous drug errors, and an often
neglected area of clinical practice, we were left somewhat perplexed as to
the authors’ understanding of ‘ethnography’. Whilst we are aware that the
use of qualitative methods in medical related research is relatively new,
we are concerned, as are others, about the quality of research that is
being published in this area. As published, this study is not an
ethnographic study and is barely qualitative.
The authors have conducted an observational study, one it seems with
roots in quantitative not qualitative methodology. This is most obvious
from the outcome measures used where the authors set out to document the
‘number, type and clinical importance of errors’. One clue to reviewers
would be the use of terms like ‘number’. Also later we find that the
researchers have used ‘a validated scale to assess the clinical importance
of intravenous drug errors’. Ethnographic studies do not rely on the use
of quantitative scale assessments. The use of ‘confidence intervals’ to
analyse supposedly ‘ethnographic data’ is again somewhat worrying. Lack of
time here precludes us from expansion, but we refer interested parties to
the following sources for an exploration of the meaning of ‘ethnography’
and ethnographic methods:
Agar, M. 1980 The Professional Stranger: An Informal Introduction to
Ethnography.
Spradley, J.P. 1979 The Ethnographic Interview.
Hammersley, M. and Atkinson P. 1995 Ethnography: Principles and
Practices.
In a broader sense, this paper raises concerns for us about the
understanding of qualitative methods in medicine. The misrepresentation of
this study as ‘ethnography’ can unfortunately do nothing but undermine the
work of qualitative researchers. Ethnographers and other qualitative
researchers are constantly called upon to defend the integrity and rigour
of their methodologies against quantitative ones and we feel it our duty
to defend proper qualitative research against methodological drift. There
already exists an abundance of misunderstanding about qualitative research
without prestigious journals like the BMJ contributing to the situation.
Competing interests:
None declared
Competing interests: No competing interests
Hardly surprising that nurses, fragmented into being all things to
all people who can see them, and unwise enough to take on such a "role",
would find themselves deskilled. And probably as damaged professionally as
the patients are clinically.
If a task(eg. IV therapy) is important enough that it threatens life
when said task is done badly, then the person doing that task, must be
doing only that task. Sadly, many nurses subscribe to the boastful claim
that they can do ten things at once, in a sort of female chauvinist
inspired way that appeals to some university lecturers.
Checking everything with another nurse, is a failed philosophy, and
not cost effective. The recent case reported where a nurse placed an
intracranial nasogastric tube, after another nurse verified the gastric
position[1], reminds one of the false sense of security found in numbers.
If taken to it’s logical extreme, this checking philosophy would find
nurses unable to drive, unless they had another nurse in the car, to make
sure that the green light really was a green light. Because if it’s not a
green light, life could be at stake!
Many nurses are techno-phobic, and won’t use the IMED intra-venous
infusion device’s secondary rate function to deliver a bolus. The machine
does it so much better.
Phillip J. Colquitt
New Farm, Queensland, Australia.
1. Metheny NA. Inadvertent intracranial nasogastric tube placement.
Am J Nurs. 2002 Aug;102(8):25-7. No abstract available. PMID: 12394035
[PubMed - indexed for MEDLINE]
Competing interests:
Machinery
Competing interests: No competing interests
This study confirms what most of us informally are aware of - when
people are under pressure performance suffers.
Whatever one knows or can do (i.e. one's competence) is not always
translated into day to day activity (performance). Who else has not taken
a short cut today in one or more clinical or administrative activities,
because they had five other important, or urgent (or both!), things to get
done before the end of the day?
There would appear to be two logical potential solutions:
a) Use infusors rather than require nurses to spend time
administering i.v. medication
b) Staff the wards sufficiently to allow nurses to have the time to
devote to this function, in addition to the multifarious other tasks
accruing in their portfolios.
The latter option would allow time for the nurses actually to have
human contact with the patient for a limited but relatively undisturbed
period of time (as when specialist oncology nurses administer cytotoxic
drugs). Given the extra cost this would represent to a resource limited
system, I think I can predict which option would be the more attractive to
someone designing a service with cost control as a (the?) significant
driver.
Competing interests:
The amount of work I would like to finish to a satisfactory standard, and the amount of time I am prepared to devote to my working life
Competing interests: No competing interests
Thank you for this article. I've been a nurse for 22 years and have
made and seen a number of i.v. drug mistakes.
One of the things that helps prevention of mistakes is the standard
check and double check protocols that are in place in most of the
hospitals in the Netherlands.
There are a few other measures that can help prevent mistakes. One of
these is the introduction of an information system like the one we have on
the intanetsite of Leiden University Hospital. In this
information system all drugs that can be administered by injection are
mentioned plus the medication it can, or does not, interact with. Also
it states the time for infusion, and the maximum dose/ml.
If this is not enough, the nurse who administers the medication can
opt for the use of the perfusor, yes the very same that is being used for
the continuous administration of medication. Its primary function is to
administer fluids, with or without medication, over a period of time. I
know that on the non-ICU wards they are not available everywhere, but in the
ICU, and especially the pediatric ICU they are "abundant", and a big help
in preventing temporary or terminal overdose.
It takes a little more time but makes and keeps you more aware of
the risks. For all nurses who do not know the effect of (temporary)
overdose, go to the ICU and see what happens when you administer a drug too
fast to an instable patient who is being monitored for ABP/HR and SP02. You will
note that it takes more time to stabilize the patient than it takes to
hook up a perfusor.
The results of the study will help me in my other job: the teaching
of nursing; most of my work involves the learning of skills in a Skillslab
setting. I've been warning students about the effect of medication mistakes,
especially too rapid infusion i.v. medication. I strongly believe that
making people/students aware of the risks is part prevention.
Thanks,
Frank Overpelt.
Competing interests:
None declared
Competing interests: No competing interests
Air in the line
Ed,
Gemini PC-1 IMED electronic infusion devices are getting some
specific attention - they need it - despite their undoubted efficiency and
elegance compared to the older manual IV fluid administration technique.
Regarding potential problems identified by trainer Steve[1], where a
bolus injection given using the secondary rate function of the IMED, is
not part of the total volume displayed. The problem barely exists, and
is virtually negated in view of the controlled rate provided by metered
bolus infusion, as against uncontrolled bolus given manually[2].
IMEDs and other such devices rarely display exact correlation between
visible contents of IV bag and total volume given via the display panel,
and most nurses make minor program adjustments of the volume to be given,
to prevent air in the line.
Serious consequences directly related to IV lines being temporarily
unprimed is hypothetical. Manufacturers of IMEDs could easily design out
the air in line effect that occurs when an infusion “runs through”. Until
then, evacuation of air in line remains a necessary nursing skill for
hands on nurses.
Phil Colquitt RN
[1] Steven J RogersRe: The checking philosophy of nurses. BMJ Rapid
Responses.(18 June 2003)
[2] Taxis K. Barber N. Ethnographic study of incidence and severity
of intravenous drug errors. BMJ 2003; 326: 684
Competing interests:
Worry
Competing interests: No competing interests