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Longitudinal study of childhood wheezy bronchitis and asthma: outcome at age 42

BMJ 2003; 326 doi: (Published 22 February 2003) Cite this as: BMJ 2003;326:422
  1. Elisabeth Horak, research fellowa,
  2. Anna Lanigan, research assistanta,
  3. Mary Roberts, research assistanta,
  4. Liam Welsh, research assistanta,
  5. John Wilson, associate professorc,
  6. John B Carlin, deputy directorb,
  7. Anthony Olinsky, directora,
  8. Colin F Robertson, associate professor (
  1. a Department of Respiratory Medicine, Royal Children's Hospital, Parkville 3052, Australia
  2. b Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville 3052, Australia
  3. c Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia
  1. Correspondence to: C F Robertson
  • Accepted 7 November 2002

Longitudinal studies have reported that asthma in childhood has a good prognosis. However, most of these studies have not taken into account the severity of childhood symptoms.1 The Melbourne Epidemiological Study of Childhood Asthma recruited children at age 7 years and followed them up through adolescence to adulthood.25 This report describes outcome at age 42 years in relation to symptoms in childhood.

Participants, methods, and results

In 1964, 401 children (295 with asthma and 106 controls) were randomly selected from a total of 30 000 7 year olds living in metropolitan Melbourne. A further 83 children with severe asthma were included from the same cohort in 1967, at age 10. 2 3 Original data were available for 479 participants. …

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