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Neurodegenerative terms

BMJ 2002; 325 doi: https://doi.org/10.1136/sbmj.0208274 (Published 01 August 2002) Cite this as: BMJ 2002;325:0208274
  1. Abi Berger1
  1. 1BMJ

ß-Amyloid: ß-Amyloid protein causes problems only when it is converted from its normal soluble form to insoluble ß-pleated sheets, which accumulate into neurotoxic amyloid plaques. In its healthy role it is probably involved in stabilising cell walls.

Prions: These are proteins produced by the prion gene and probably have a role in maintaining the electrical activity of cells. In Creutzfeldt-Jakob disease, the normal soluble form changes its configuration …

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