Diana Kuh, Rebecca Hardy, Claudia Langenberg, Marcus Richards, Michael E J Wadsworth
Kuh D, Hardy R, Langenberg C, Richards M, Wadsworth M E J.
Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study
BMJ 2002; 325 :1076
doi:10.1136/bmj.325.7372.1076
Mortality in adults: the primay role of mitochondrial DNA.
Sirs,
Socioeconomic conditions in childhood as well as early adulthood have
strongly influenced the survival of British people (and likely of other
people around the world, so I think), born in the immediate post war era
(1). On the other hand, associations between socioeconomic conditions in
childhood and mortality in adulthood suggest clearly that risks to
survival begin in early life. In addition, individuals for whom
socioeconomic disadvantage continue into early adulthood result between
three and five times more likely to die than those in the most
advantageous conditions. From these remarks, one can suspect that death
rate in adulthood is chiefly ruled by environmental conditions,
independently from genetic factors, upon which, on the contrary, the
former are acting, as I described in previous papers (2, 3, 4).
Interestingly, I demonstrated that elderly people, over 90 years, present
allways high tissue level of Co Q10 (5), indicating that one “can” die of
old age, although sometime poor socioeconomic conditions in childhood, if
only mitochondria, or more precisely speaking, mit-DNA, inherited mainly
from mother, are well functioning. In my opinion, physicians around the
world, have unfortunately insufficient, poor, knowledge about such a
paramount topic, i.e., mit-DNA function, which now-a-days can be
accurately assessed at the bed-side with the aid of Biophysical Semeiotics
(See my site, HONCode N° 233736,
http://digilander.libero.it/semeioticabiofisica).
1) Kuh D., Hardy R, Langenberg C., et al. Mortality in adults aged 26
-54 years related to socioeconomic conditions in childhood and adulthood:
post war birth cohort study. BMJ 2002;325:1076-1080 ( 9 November).
2) Stagnaro S. Istangiopatia Congenita Acidosica Enzimo-Metabolica
condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz.
Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28
Settembre-1 Ottobre, 1985 Bellagio.
3) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. X
Congr. Naz. Soc. It. di Microangiologia e Microcircolazione. Atti, 61. 6-7
Novembre, 1981, Siena.
4) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una
Patologia Mitocondriale Ignorata. Gazz Med. It. – Arch. Sci. Med. 144,
423, 1985 (Infotrieve).
5) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria
da carenza di Co Q10. Medic. Geriatr. XXIV, 239, 1993.
Competing interests:
None declared
Competing interests: No competing interests