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Interrupting antiretroviral treatment fails to improve chronic HIV

BMJ 2002; 325 doi: (Published 05 October 2002) Cite this as: BMJ 2002;325:736
  1. Xavier Bosch
  1. Barcelona

    An idea that doctors can enhance specific cellular immune responses and decrease the number of viruses in the blood of patients with chronic HIV infection by regularly repeated interruptions of antiretroviral treatment may have been disproved by new research. Such interruption of treatment should not be pursued in people with chronic HIV infection, the scientists advise.

    Increasing concerns over the long term toxicity of antiretroviral drugs, the increasing prevalence of resistance to the drugs, and the cost of continuous treatment have prompted researchers to explore other approaches, such as delaying treatment or administering the drugs intermittently.

    It has been thought that repeated interruption can enhance HIV specific immunity. This is thought to occur …

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