Brian McArdle

BMJ 2002; 325 doi: (Published 31 August 2002) Cite this as: BMJ 2002;325:497

One of the last to give his name to an eponymous disease

In a 1951 paper in the journal Clinical Science Brian McArdle described a 30 year old man experiencing pain followed by weakness and stiffness after exercise. These symptoms had been regarded as psychological, but McArdle noted that the man's muscles were electrically silent, unlike ordinary cramp, and that his venous lactate level failed to increase after ischaemic exercise. He realised that this was the same phenomenon that occurs when …

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