Initial antiretroviral regimens

BMJ 2002; 324 doi: https://doi.org/10.1136/bmj.324.7340.747 (Published 30 March 2002) Cite this as: BMJ 2002;324:747

In general three drugs are better than two are better than one

  1. Charles Carpenter, professor of medicine
  1. Department of Medicine, Brown Medical School, Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA

    Papers p 757

    In this issue Rachel Jordan and colleagues have provided a meta-analysis of published controlled clinical trials, which provide significant information relevant to the initial treatment of established HIV infection in adults and adolescents (p 757).1 Their analyses are based on a large number of well conducted clinical trials. The data largely confirm earlier observations, often from relatively small studies, which have shown that dual nucleoside antiretroviral regimens are significantly more effective than single nucleoside therapy, and that three drug antiretroviral regimens are significantly better than two drug regimens for initial therapy of HIV infection.

    The conclusions of the meta-analysis are entirely consistent with current consensus recommendations that initial therapy for established HIV infection in adults and adolescents should include a combination of three potent antiretroviral …

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