Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis
BMJ 2002; 324 doi: https://doi.org/10.1136/bmj.324.7330.144 (Published 19 January 2002) Cite this as: BMJ 2002;324:144- Andreas Schapowal, consultant in ear, nose, and throat medicine (andreas.schapowal{at}freesurf.ch) Petasites Study Group
- Accepted 13 September 2001
Abstract
Objectives: To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever).
Design: Randomised, double blind, parallel group comparison.
Setting: Four outpatient general medicine and allergy clinics in Switzerland and Germany.
Participants: 131 patients were screened for seasonal allergic rhinitis and 125 patients were randomised (butterbur 61; cetirizine 64).
Interventions: Butterbur (carbon dioxide extract tablets, ZE 339) one tablet, four times daily, or cetirizine, one tablet in the evening, both given for two consecutive weeks.
Main outcome measures: Scores on SF-36 questionnaire and clinical global impression scale.
Results: Improvement in SF-36 score was similar in the two treatment groups for all items tested hierarchically. Butterbur and cetirizine were also similarly effective with regard to global improvement scores on the clinical global impression scale (median score 3 in both groups). Both treatments were well tolerated. In the cetirizine group, two thirds (8/12) of reported adverse events were associated with sedative effects (drowsiness and fatigue) despite the drug being considered a non-sedating antihistamine.
Conclusions: The effects of butterbur are similar to those of cetirizine in patients with seasonal allergic rhinitis when evaluated blindly by patients and doctors. Butterbur should be considered for treating seasonal allergic rhinitis when the sedative effects of antihistamines need to be avoided.
What is already known on this topic
What is already known on this topic Seasonal allergic rhinitis (hay fever) is common in countries with temperate climates.
Most patients have their symptoms treated for short periods, particularly during peaks in atmospheric pollen count
What this study adds
What this study adds After two weeks, the effects of butterbur and cetirizine were comparable in patients with hay fever
Butterbur produced fewer sedating effects than cetirizine
Butterbur should be considered when the sedating effects of antihistamines must be avoided
Footnotes
-
Funding Zeller AG (Switzerland) supplied study medication and sponsored the study through the Clinical Research Organisation Praxis Klinische Arzneimittelforschung, Pohlheim, Germany. The interpretation of the results was the prerogative of the principal investigator and the study group.
-
Competing interests None declared.
- Accepted 13 September 2001